PMID: 11315625Apr 24, 2001Paper

Comparative ultrastructural study of cytotoxic granules in nasal natural killer cell lymphoma, intestinal T-cell lymphoma, and anaplastic large cell lymphoma

Virchows Archiv : an International Journal of Pathology
Y SadahiraT Manabe

Abstract

Comparative immunohistochemical and ultrastructural studies were performed on five nasal natural killer (NK) cell lymphoma cases, two intestinal T-cell lymphoma cases, and eight anaplastic large cell lymphoma (ALCL) cases to clarify morphological differences in cytotoxic granules among these cytotoxic lymphomas. Nasal NK-cell lymphomas and intestinal T-cell lymphomas had fine azurophilic granules and displayed dot-like immunostaining of granzyme B- and T-cell intracellular antigen 1 (TIA-1), predominantly in the central area of the cytoplasm. Ultrastructurally, these NK-cell lymphomas and intestinal T-cell lymphomas had two types of cytotoxic granules, type-I granules (dense core granules) and type-II granules (multivesicular bodies), which have been demonstrated in normal large granular lymphocytes in peripheral blood. However, ALCLs did not have azurophilic granules, and only type-II cytotoxic granules were found ultrastructurally, even though they showed similar dot-like immunostained patterns of granzyme B and TIA-1, as seen in NK-cell lymphomas and intestinal T-cell lymphomas. Immunoelectron microscopy revealed that TIA-1 was primarily located at the periphery of the cytoplasmic granules in the NK-cell lymphoma and ALCL ca...Continue Reading

Citations

Aug 2, 2003·Journal of Clinical Pathology·Y SadahiraT Manabe
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dongfang LiuTao Xu
Feb 2, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Bill H ChangGuang Fan
Nov 18, 2009·Annals of Diagnostic Pathology·Steven GustafsonCarlos E Bueso-Ramos
Aug 30, 2014·Molecular Cancer·Joel D PearsonRobert J Ingham
Nov 5, 2014·Journal of Korean Neurosurgical Society·Tae Keun JeeHyung Jin Shin
Oct 9, 2007·British Journal of Neurosurgery·Ercan OzerSerafettin Canda

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