Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ping LiChunlin Long

Abstract

Garcinia oblongifolia Champ. ex Benth. (Clusiaceae) is a well-known medicinal plant from southern China, with edible fruits. However, the phytochemistry and bioactivity of the different plant parts of G. oblongifolia have not been studied extensively. Comparative metabolic profiling and bioactivities of the leaf, branch, and fruit of G. oblongifolia were investigated. A total of 40 compounds such as biflavonoids, xanthones, and benzophenones were identified using UPLC-QTOF-MS and MS(E), including 15 compounds reported for the first time from this species. Heatmap analyses found that benzophenones, xanthones, and biflavonoids were predominately found in branches, with benzophenones present in relatively high concentrations in all three plant parts. Xanthones were found to have limited distribution in fruit while biflavonoids were present at only low levels in leaves. In addition, the cytotoxic (MCF-7 breast cancer cell line) and antioxidant (ABTS and DPPH chemical tests) activities of the crude extracts of G. oblongifolia indicate that the branch extract exhibits greater bioactivity than either the leaf or the fruit extracts. Orthogonal partial least squares discriminate analysis was used to find 12 marker compounds, mainly xant...Continue Reading

References

May 1, 1987·Biochemical Pharmacology·R C SmithR A Schnettler
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Oct 27, 2004·Phytochemistry·Joumaa MerzaPascal Richomme
Aug 23, 2005·Phytochemistry·S DeachathaiW C Taylor
Oct 28, 2005·Current Medicinal Chemistry·M M M PintoM S J Nascimento
Jun 23, 2009·Journal of the American Society for Mass Spectrometry·Anna Lisa PiccinelliLuca Rastrelli
Mar 12, 2011·Journal of Agricultural and Food Chemistry·Keyvan DastmalchiEdward J Kennelly
Apr 20, 2013·Journal of Agricultural and Food Chemistry·Shi-Biao WuShengping Zheng
Oct 2, 2013·Natural Product Research·Shixiu FengTao Chen
Apr 24, 2014·Journal of Natural Products·Chao FengKathy Qian Luo
Jun 28, 2014·Natural Product Reports·Shi-Biao WuEdward J Kennelly
Nov 6, 2014·PloS One·Wankun DengYu Xue

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Citations

Jun 13, 2019·Natural Product Reports·Lindsay K Caesar, Nadja B Cech
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tongchai SaesongKornkanok Ingkaninan
Jul 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simone da Cunha DemencianoDanielle Bogo
Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhijun WuHong Wang
Jan 19, 2021·Mitochondrial DNA. Part B, Resources·Xiang MaLiang Tang
Feb 13, 2021·Natural Product Research·Binsheng LuoChunlin Long
Sep 30, 2021·Natural Products and Bioprospecting·Christian Bailly, Gérard Vergoten

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