PMID: 2117431Jan 1, 1990Paper

Comparative uptake, vascular transport, and cellular internalization of aflatoxin-B1 and benzo(a)pyrene

Archives of Toxicology
D L BusbeeR L Ziprin

Abstract

Studies of the uptake of benzo(a)pyrene (BaP) and aflatoxin-B1 (AFB1) after gastric instillation showed that BaP was absorbed via the intestinal lymphatic drainage and transported to the vascular circulation sequestered within lipoproteins in thoracic duct lymph, while AFB1 was absorbed with water soluble compounds into the gastrointestinal venous drainage and was not transported in association with lipoproteins. BaP was taken up into plasma lipoproteins over a broad concentration range, while AFB1 was not sequestered within lipoproteins over the same concentration range. Low density lipoproteins (LDL) facilitated BaP uptake into fibroblasts and impeded BaP uptake into hepatocytes. High density lipoproteins (HDL) facilitated BaP uptake into hepatocytes and impeded BaP uptake into fibroblasts. The uptake of AFB1 into either fibroblasts or hepatocytes was not affected by lipoproteins.

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Citations

Oct 23, 2010·Journal of Toxicology and Environmental Health. Part a·Aramandla RameshMohammad S Niaz
Oct 6, 2007·Cell Stress & Chaperones·Hadi FalahatpishehKenneth S Ramos
May 25, 2012·Proteomics·Nisha VermaSimone Schmitz-Spanke
Jan 11, 2012·Environmental Pollution·Stéphane ReynaudMuriel Raveton
Nov 16, 2013·The Journal of Nutritional Biochemistry·Deacqunita L DiggsAramandla Ramesh
Jan 28, 2016·Environmental Toxicology and Chemistry·Rachel E PetersSteven D Siciliano
Oct 30, 2004·International Journal of Toxicology·Aramandla RameshEric H Weyand
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Mar 26, 2013·FEBS Letters·Marta Vieira, Maria João Saraiva
Jan 1, 1994·Archives of Toxicology·D L Busbee, R L Ziprin
May 19, 2020·Molecular Nutrition & Food Research·Ixchel Gilbert-SandovalIvonne M C M Rietjens
Oct 23, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·A RameshA M Nyanda

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