Comparative Utility of Manual versus Automated Segmentation of Hippocampus and Entorhinal Cortex Volumes in a Memory Clinic Sample

Journal of Alzheimer's Disease : JAD
Yi Leng FungStephen C Bowden

Abstract

Structural neuroimaging is a useful non-invasive biomarker commonly employed to evaluate the integrity of mesial temporal lobe structures that are typically compromised in Alzheimer's disease. Advances in quantitative neuroimaging have permitted the development of automated segmentation protocols (e.g., FreeSurfer) with significantly increased efficiency compared to earlier manual techniques. While these protocols have been found to be suitable for large-scale, multi-site research studies, we were interested in assessing the practical utility and reliability of automated FreeSurfer protocols compared to manual volumetry on routinely acquired clinical scans. Independent validation studies with newer automated segmentation protocols are scarce. Two FreeSurfer protocols for each of two regions of interest-the hippocampus and entorhinal cortex-were compared against manual volumetry. High reliability and agreement was found between FreeSurfer and manual hippocampal protocols, however, there was lower reliability and agreement between FreeSurfer and manual entorhinal protocols. Although based on a the relatively small sample of subjects drawn from a memory clinic (n = 27), our study findings suggest further refinements to improve mea...Continue Reading

References

Aug 1, 1992·Brain : a Journal of Neurology·M J CookJ M Stevens
Nov 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·R KikinisH Cline
Jan 1, 1993·European Neurology·H BraakJ Bohl
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Sep 29, 1999·Statistical Methods in Medical Research·J M Bland, D G Altman
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Jul 15, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M Bland, D G Altman
May 5, 2004·Neurobiology of Aging·Corina PennanenHilkka Soininen
Aug 18, 2004·Neurobiology of Aging·Leyla deToledo-MorrellD A Turner
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Sep 4, 2007·Seizure : the Journal of the British Epilepsy Association·Catherine E MeadeMark J Cook
Apr 21, 2009·NeuroImage·Bruce FischlJean C Augustinack
Jul 21, 2009·Medical Physics·Jeffrey L GunterClifford R Jack
Sep 2, 2009·Clinical and Experimental Pharmacology & Physiology·John Ludbrook
Nov 13, 2009·Annals of the New York Academy of Sciences·Andrew SimmonsUNKNOWN AddNeuroMed Consortium
Jul 6, 2010·NeuroImage·Josephine BarnesNick C Fox
Oct 13, 2010·Journal of the International Neuropsychological Society : JINS·C C PriceI Schmalfuss
Oct 28, 2010·Expert Review of Neurotherapeutics·Linda K McEvoy, James B Brewer
Dec 16, 2010·International Journal of Geriatric Psychiatry·Andrew SimmonsChristian Spenger
Mar 25, 2011·Neuropsychiatric Disease and Treatment·Marlene Oscar-Berman, Janet Song
Jul 19, 2011·NeuroImage·Eric WestmanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 7, 2011·Neurobiology of Aging·Clifford R Jack
Jan 18, 2012·NeuroImage·Bruce Fischl
Sep 1, 2012·Human Brain Mapping·Edit FrankóChantal Chavoix
Nov 1, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T WymanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 10, 2013·Biological Psychiatry·Courtney L SutphenDavid M Holtzman

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Software Mentioned

Freesurfer
Ubuntu Linux
erc
hippocampal subfields package
FS exvivo
Analyze
FS erc

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