PMID: 11332460May 3, 2001Paper

Comparative utility of technetium-99m hexamethylpropylenamine oxime single photon emission computed tomography (SPECT) with anatomic neuroimaging and electroencephalography (EEG) in childhood intractable epilepsy

Journal of Child Neurology
V KalraM Bhatia

Abstract

Intractable epilepsies pose a therapeutic challenge. Precise localization of the epileptic focus is imperative before planning surgical intervention. Functional imaging is an important component of presurgical work-up. Positron emission tomography is unavailable in developing countries; hence, the need to evaluate the available imaging modality, single photon emission computed tomography (SPECT), was felt. We investigated 61 children with intractable epilepsy, identified by predefined criteria, by performing electroencephalography (EEG), magnetic resonance imaging (MRI), computed tomography (CT), and ictal and interictal SPECT. The localizing value of ictal and interictal SPECT imaging for epileptic foci was correlated with clinical, electrophysiologic, and anatomic neuroimaging data. An ictal SPECT was obtained in 9, and interictal SPECT was performed in all (61). Ictal SPECT was localizing in 8 of 9 (88.8%). Interictal SPECT was localizing in a significantly higher proportion of patients (47.54%) than either the scalp EEG (16.39%) (P = .0003) or CT scan (21.56%) (P = .0046). Our data demonstrated that interictal and ictal SPECT identified more focal changes in children with intractable epilepsy than interictal EEG, CT, and pr...Continue Reading

References

Sep 1, 1986·Nuclear Medicine Communications·D C CostaP H Jarritt
Jul 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·M R NewtonP F Bladin
Sep 1, 1993·Epilepsia·E WyllieH Lüders
Sep 1, 1995·Clinical Nuclear Medicine·E AlperO Eralp
Dec 24, 1997·Acta Neurologica Scandinavica·U RungeC Kessler
Nov 1, 1991·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·R KuznieckyE Faught

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Citations

Apr 29, 2008·Neuro-Chirurgie·C Chiron, L Hertz-Pannier

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