Comparative virulence of Haemophilus influenzae with a type b or type d capsule.

Infection and Immunity
M RobertsA L Smith

Abstract

To determine the importance of specific capsule type in the pathogenesis of invasive Haemophilus influenzae disease, we compared the virulence of type b and type d strains isolated from different children with the virulence of transformation-derived type b and type d organisms. In addition, the unencapsulated derivative of these strains was also examined. Virulence was assessed by determining the ability of the strains to produce bacteremia with intranasal or subcutaneous inoculation. Unencapsulated derivatives were unable to cause bacteremia by any route; all type b strains (whether natural or derived by transformation), a natural type d, and a type d derived by transformation were able to produce bacteremia with similar frequency (42 to 62%) when 10(7) colony-forming units was given intranasally. Subcutaneous inoculation of 10(3) colony-forming units of strains with the type b capsule produced bacteremia at a greater frequency than did the strains with the type d capsule (P less than 0.002). The type d isolate was more virulent than a mutagenized derivative of the strain. We conclude that the type b strains are more virulent than type d when inoculated subcutaneously.

References

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Citations

May 1, 1991·Infection·M PowellD M Livermore
Apr 5, 2003·Journal of Medical Microbiology·Dayle A DainesArnold L Smith
Apr 1, 1994·Acta Paediatrica Japonica; Overseas Edition·T SakanoH Takahashi
Nov 21, 2009·Journal of Medical Microbiology·S WarrenR S Bradbury
Jan 1, 1984·Infection·A L SmithR D Toothaker
Apr 1, 1993·Clinical Microbiology Reviews·A R Tunkel, W M Scheld
Sep 1, 1983·Journal of Clinical Microbiology·R L Holmes, W P Kozinn
Aug 1, 1985·Antimicrobial Agents and Chemotherapy·M C RobertsJ H Crosa
Nov 1, 1995·Infection and Immunity·P A TottenW E Stamm
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·R de GrootA L Smith
Jan 1, 1985·Antimicrobial Agents and Chemotherapy·J L BurnsA L Smith
Dec 1, 1994·Infection and Immunity·P A TottenW E Stamm
Sep 1, 1982·Antimicrobial Agents and Chemotherapy·P M MendelmanA L Smith
Aug 1, 1983·Journal of Bacteriology·L van AlphenH C Zanen
Apr 1, 1988·Infection and Immunity·K A PidcockT L Stull
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·P M MendelmanA L Smith

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