Comparative volumetric analysis of the extent of resection of molecularly and histologically distinct low grade gliomas and its role on survival

Journal of Neuro-oncology
Chikezie I EseonuAlfredo Quinones-Hinojosa

Abstract

The authors investigate the role of extent of resection (EOR) and genetic markers on patient outcome and survival for LGGs. We conducted a retrospective cohort between 2005 and 2015, of 109 adult patients who underwent surgery for a LGG by a single surgeon. Volumetric computations of MRI studies were conducted to evaluate the EOR, and genetic markers (IDH1, 1p/19q co-deletion, and p53) were assessed and their effects on survival and neurological outcome were evaluated. The median EOR was 88.1%. Permanent postoperative neurological deficits were seen in 4.6% of patients. EOR was a significant predictor for both overall survival (OS) (hazard ratio [HR] = 0.979, 95% CI 0.961-0.980, p = 0.029) and progression free survival (PFS) (HR = 0.982, 95% CI 0.968-0.997, p = 0.018). Malignant progression free survival (MPFS) was predicted by the 1p/19q co-deletion (HR = 0.148, 95% CI 0.019-1.148, p = 0.048). Patients with EOR of 100% had a significantly better OS than EOR less than 90% (p = 0.038). Patients with an EOR of at least 76% had a better OS than EOR less than 76% (p = 0.025). Patients with an EOR of at least 71% had a better PFS than EOR less than 71% (p = 0.030). Preoperative tumor volume was found to have significant association ...Continue Reading

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Citations

Nov 24, 2018·Journal of Neuro-oncology·Daniel DelevOliver Schnell
Jan 22, 2020·Journal of Neurosurgical Sciences·Jorge Navarro-BonnetAlfredo Quinones-Hinojosa
Jun 30, 2019·AJNR. American Journal of Neuroradiology·S H PatelD Schiff
Jun 12, 2020·Journal of Neuro-oncology·Karim ReFaeyAlfredo Quinones-Hinojosa
Dec 21, 2017·Brain Sciences·Montserrat Lara-VelazquezAlfredo Quinones-Hinojosa
Oct 22, 2020·Cancers·Giuseppe LombardiTamara Ius
Jul 19, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ronald M Juarez-ChambiJavier A Jo
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini Sundramurthi ChelliahIshwar Parhar
May 13, 2021·Scientific Reports·Tamara IusMiran Skrap
May 16, 2021·Journal of Biomechanical Engineering·Zheng FangBing Zhang
Jun 24, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Weller
Aug 4, 2021·Journal of Neurology·Annette LeibetsederAnna Sophie Berghoff

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