Comparatively weak after-effects of transcranial alternating current stimulation (tACS) on cortical excitability in humans

Brain Stimulation
Andrea AntalWalter Paulus

Abstract

Interference with brain rhythms by noninvasive transcranial stimulation that uses weak transcranial alternating current may reveal itself to be a new tool for investigating cortical mechanisms currently unresolved. Here, we aim to extend transcranial direct current stimulation (tDCS) techniques to transcranial alternating current stimulation (tACS). Parameters such as electrode size and position were taken from those used in previous tDCS studies. Motor evoked potentials (MEPs) revealed by transcranial magnetic stimulation (TMS), electroencephalogram (EEG)-power, and reaction times measured in a motor implicit learning task, were analyzed to detect changes in cortical excitability after 2-10 minutes of AC stimulation and sinusoidal DC stimulation (tSDCS) by using 1, 10, 15, 30, and 45 Hz and sham stimulation over the primary motor cortex in 50 healthy subjects (eight-16 subjects in each study). A significantly improved implicit motor learning was observed after 10 Hz AC stimulation only. No significant changes were observed in any of the analyzed frequency bands of EEG and with regard to the MEP amplitudes after AC or tSDCS stimulation. Similarly, if the anodal or cathodal DC stimulation was superimposed on 5, 10, and 15 Hz AC ...Continue Reading

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Citations

Aug 9, 2011·Neuropsychological Rehabilitation·Walter Paulus
Sep 29, 2011·Neuropsychological Rehabilitation·Satoshi TanakaLeonardo G Cohen
Apr 13, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Sven Vanneste, Dirk De Ridder
Jun 10, 2011·Journal of Visualized Experiments : JoVE·Alexandre F DaSilvaFelipe Fregni
Jul 16, 2013·Journal of Visualized Experiments : JoVE·Pedro SchestatskyFelipe Fregni
Oct 1, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shapour JaberzadehMaryam Zoghi
Mar 4, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A Bastani, S Jaberzadeh
Jun 6, 2014·Electromagnetic Biology and Medicine·Sajedeh Yadegari-DehkordiAmeneh Sazgarnia
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Nov 12, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Paul B Fitzgerald
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Oct 2, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Walter Paulus, Alexander Opitz
Apr 23, 2011·Brain Stimulation·Dennis J L G Schutter, Ruud Hortensius
Feb 26, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Walter Paulus
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Jan 1, 2009·Brain Stimulation·Ying-Zu HuangYoshikazu Ugawa
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May 2, 2013·Annals of the New York Academy of Sciences·Sven Bestmann, Eva Feredoes
Aug 27, 2015·Wiley Interdisciplinary Reviews. Cognitive Science·Andrea AntalLeila Chaieb
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Oct 7, 2015·Frontiers in Cellular Neuroscience·Géza Gergely AmbrusAndrea Antal
Sep 1, 2015·Frontiers in Cellular Neuroscience·Daniel StrüberChristoph S Herrmann
Apr 18, 2016·Neuropsychologia·Dennis J L G Schutter, Miles Wischnewski
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Jun 18, 2015·Frontiers in Behavioral Neuroscience·Leila ChaiebWalter Paulus
Jul 31, 2013·Current Biology : CB·Emiliano SantarnecchiSimone Rossi
Jul 28, 2012·NeuroImage·T NeulingC S Herrmann

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