Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days post-kidney transplantation

Transplantation
José G G OliveiraM Pestana

Abstract

The new immunosuppressive drug Rapamycin (Rapa) is endowed with a mechanism of action that is distinct from that of calcineurin inhibitors. It has been claimed that Rapa does not significantly modulate either the cytokine expression or the transcription of several growth factors in mitogen-activated T cells. Previously, we reported that fine-needle aspiration biopsy (FNAB) sample cultures synthesize a large array of cytokines, and some of them may be powerful predictors of acute rejection in renal transplants. We hypothesized that Rapa may induce significant changes on cytokine production by FNAB sample cultures and on serum cytokine receptors when compared to other immunosuppressive drugs. Kidney transplants treated with CsA-Rapa-Pred (Rapa group) were compared with transplants treated with CsA-mycophenolate mofetil-Pred (MMF group). They were studied on day 7 posttransplantation, and they remained rejection free for at least the first 6 months. FNAB samples were cultured and the supernatants were collected at 48 hr of incubation and analyzed by ELISA for interleukin 1 receptor antagonist (IL-1ra), IL-2, IL-6, IL-10, IL-18, monocyte chemotactic protein 1 (MCP-1), soluble tumor necrosis factor I, and transforming growth factor ...Continue Reading

References

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Citations

Sep 1, 2005·The Journal of Experimental Medicine·Shaowei LiThomas N Darling
Jul 21, 2005·Clinical Pharmacokinetics·Sunita Bond StentonMary H H Ensom
May 30, 2006·Kidney International·M-J WuM-J Tang
Sep 16, 2006·The International Journal of Biochemistry & Cell Biology·Catherine E WinbanksGavin J Becker
Sep 3, 2016·Apoptosis : an International Journal on Programmed Cell Death·Joanna Kabat-KoperskaKazimierz Ciechanowski
Oct 11, 2016·Cellular & Molecular Immunology·Rita DiehlJohannes Boltze
Nov 17, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Guoqiang ZhangHidetaka Hara
Dec 19, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Benjamin J KopeckyKory J Lavine
Feb 27, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kun L MaZac Varghese
Mar 7, 2017·Frontiers in Immunology·Thierry P P van den BoschAjda T Rowshani
Jun 12, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Karolina KędzierskaKazimierz Ciechanowski
Jan 11, 2020·Frontiers in Immunology·Gianluigi ZazaPaolo Cravedi

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