Comparing adult cannabis treatment-seekers enrolled in a clinical trial with national samples of cannabis users in the United States

Drug and Alcohol Dependence
Erin A McClureKevin M Gray

Abstract

Cannabis use rates are increasing among adults in the United States (US) while the perception of harm is declining. This may result in an increased prevalence of cannabis use disorder and the need for more clinical trials to evaluate efficacious treatment strategies. Clinical trials are the gold standard for evaluating treatment, yet study samples are rarely representative of the target population. This finding has not yet been established for cannabis treatment trials. This study compared demographic and cannabis use characteristics of a cannabis cessation clinical trial sample (run through National Drug Abuse Treatment Clinical Trials Network) with three nationally representative datasets from the US; 1) National Survey on Drug Use and Health, 2) National Epidemiologic Survey on Alcohol and Related Conditions-III, and 3) Treatment: Episodes Data Set - Admissions. Comparisons were made between the clinical trial sample and appropriate cannabis using sub-samples from the national datasets, and propensity scores were calculated to determine the degree of similarity between samples. showed that the clinical trial sample was significantly different from all three national datasets, with the clinical trial sample having greater rep...Continue Reading

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Citations

May 22, 2019·The American Journal of Drug and Alcohol Abuse·Joao P De AquinoRobert Rosenheck
Jun 13, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer DahneMatthew J Carpenter
Feb 15, 2020·Clinical and Translational Science·Zhe HeJiang Bian
Jan 20, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Joanna S ZeigerRobert S Zeiger

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