Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using electronic health records.

Age and Ageing
R. OwenJay Banerjee

Abstract

The aim of this study was to describe outcomes in hospitalised older people with different levels of frailty and COVID-19 infection. We undertook a single-centre, retrospective cohort study examining COVID-19-related mortality using electronic health records, for older people (65 and over) with frailty, hospitalised with or without COVID-19 infection. Baseline covariates included demographics, early warning scores, Charlson Comorbidity Indices and frailty (Clinical Frailty Scale, CFS), linked to COVID-19 status. We analysed outcomes on 1,071 patients with COVID-19 test results (285 (27%) were positive for COVID-19). The mean age at ED arrival was 79.7 and 49.4% were female. All-cause mortality (by 30 days) rose from 9 (not frail) to 33% (severely frail) in the COVID-negative cohort but was around 60% for all frailty categories in the COVID-positive cohort. In adjusted analyses, the hazard ratio for death in those with COVID-19 compared to those without COVID-19 was 7.3 (95% CI: 3.00, 18.0) with age, comorbidities and illness severity making small additional contributions. In this study, frailty measured using the CFS appeared to make little incremental contribution to the hazard of dying in older people hospitalised with COVID-...Continue Reading

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Jul 20, 2020·European Geriatric Medicine·Amy MilesDaniel Davis
Jan 24, 2021·Journal of the American Medical Directors Association·Ruth PiersNele Van Den Noortgate
Dec 23, 2020·Archives of Gerontology and Geriatrics·Raymond PranataSiti Setiati
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Jul 7, 2021·International Journal of Clinical Practice·Jose-Manuel Ramos-RinconUNKNOWN COVID-19 ALC Research Group

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Methods Mentioned

BETA
reverse transcription PCR

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