Comparing Cervical Cytology and Histology Among Human Papillomavirus-Vaccinated and -Unvaccinated Women in an Academic Colposcopy Clinic

Obstetrics and Gynecology
Benjamin J DortonSarah Feldman

Abstract

To analyze differences in cytology and histology results between patients previously vaccinated against human papillomavirus (HPV) compared with unvaccinated patients who presented to an academic colposcopy clinic for evaluation of abnormal cervical cytology. Using data from a patient registry from 2007 to 2014, we examined 1,662 patients aged 26 years or younger at the time of presentation. Demographics, HPV vaccination status, smoking, pregnancy history, sexually transmitted infections, number of sexual partners, contraception, immunosuppression, and other relevant medical issues were reviewed. Cytology and histology results were compared between previously HPV-vaccinated and unvaccinated women to determine if there was a difference in the severity of subsequent cytologic or pathologic specimens. In multivariable analyses, women who previously received at least one dose of the HPV vaccine had 53% (adjusted odds ratio [OR] 0.47, 95% confidence interval [CI] 0.34-0.66; P<.001) lower odds of presenting with high-grade cytology (adenocarcinoma in situ, atypical glandular cells, atypical squamous cells cannot rule out high grade, and high-grade squamous intraepithelial lesion) and 36% (adjusted OR 0.64, 95% CI 0.48-0.85; P=.002) l...Continue Reading

References

Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Apr 3, 2003·Journal of Psychosomatic Research·Bruno BaldaroCarlo Flamigni
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T LeM Fung Kee Fung
Sep 5, 2006·Vaccine·D Maxwell Parkin, Freddie Bray
May 15, 2007·The New England Journal of Medicine·UNKNOWN FUTURE II Study Group
May 15, 2007·The New England Journal of Medicine·Suzanne M GarlandUNKNOWN Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators
Sep 11, 2007·Lancet·Mark SchiffmanSholom Wacholder
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
Mar 15, 2013·Journal of the National Cancer Institute·Amy LevalLisen Arnheim-Dahlström
May 3, 2013·Obstetrics and Gynecology·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
Nov 14, 2013·Gynecologic Oncology·Ida J KorfageMarjolein van Ballegooijen

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Citations

Apr 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard H BaileyCharles D Blanke
May 26, 2018·Journal of Lower Genital Tract Disease·Walter K KinneyGeorge F Sawaya
Dec 24, 2015·Obstetrics and Gynecology·Benjamin J DortonSarah Feldman
Aug 28, 2018·Current Problems in Cancer·Rebecca B PerkinsRichard S Guido

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