Comparing different estimated glomerular filtration rate equations in assessing glomerular function in children based on creatinine and cystatin C

Journal of Clinical Laboratory Analysis
Seçil ConkarGülden Hakverdi

Abstract

Glomerular filtration rate (GFR) is the best marker used to assess renal function. Estimated GFR (eGFR) equations have been developed, and the ideal formula is still under discussion. We wanted to find the most practical and reliable GFR in eGFR formulas. We compared serum creatinine (Scr)- and cystatin C (cysC)-based eGFR formulas in the literature. We also aimed to determine the suitability and the reliability of cysC for practical use in determining GFR in children. We have enrolled 238 children in the study. Measurement of 24-hour creatinine clearance was compared with eGFR equations which are based on Scr, cysC, and creatinine plus cysC. Of the patients (n = 238), 117 were males (49.2%), and 121 (50.8%) were females with a median age of 9.0 years. The areas under the ROC curves of Counahan-Barratt and Bedside Schwartz were equal and 0.89 (with a 95% CI 0.80-0.97). The areas under the ROC curves were not significantly different in all cystatin C-based eGFR equations. The highest AUC values for differentiating normal vs abnormal renal functions according to CrCl24 were for the CKiD-cysC and CKiD-Scr-cysC equations. In our study, compared with creatinine-based ones, the cystatin C-based formulas did not show much superiority ...Continue Reading

References

Nov 1, 1976·Archives of Disease in Childhood·R CounahanT M Barratt
Feb 26, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·E VingeA Grubb
Aug 16, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Nathalie Lepage
Sep 19, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Frans J HoekRaymond T Krediet
Mar 18, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·A LarssonL O Hansson
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Christine WhiteGreg A Knoll
Dec 24, 2005·Journal of the American Society of Nephrology : JASN·Andre MattmanColin Thomas White
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Jul 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael ZappitelliLorraine Bell
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Dana F Work, George J Schwartz
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Jan 1, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Ulf NymanAnders Grubb
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George J Schwartz, Dana F Work
Dec 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Justine BacchettaLaurence Dubourg
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ajay P SharmaGuido Filler
Nov 13, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ingrid MassonChristophe Mariat
May 21, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Inga SoveriUNKNOWN SBU GFR Review Group
Apr 27, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hans Pottel

❮ Previous
Next ❯

Citations

May 8, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xinmin HuHongyu Deng
Nov 16, 2018·Frontiers in Cellular Neuroscience·Yan ShiHanyu Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Michael ZappitelliLorraine Bell
Transplant International : Official Journal of the European Society for Organ Transplantation
Doris WagnerAlexander R Rosenkranz
© 2022 Meta ULC. All rights reserved