Comparing estimates of genetic variance across different relationship models

Theoretical Population Biology
Andres Legarra

Abstract

Use of relationships between individuals to estimate genetic variances and heritabilities via mixed models is standard practice in human, plant and livestock genetics. Different models or information for relationships may give different estimates of genetic variances. However, comparing these estimates across different relationship models is not straightforward as the implied base populations differ between relationship models. In this work, I present a method to compare estimates of variance components across different relationship models. I suggest referring genetic variances obtained using different relationship models to the same reference population, usually a set of individuals in the population. Expected genetic variance of this population is the estimated variance component from the mixed model times a statistic, Dk, which is the average self-relationship minus the average (self- and across-) relationship. For most typical models of relationships, Dk is close to 1. However, this is not true for very deep pedigrees, for identity-by-state relationships, or for non-parametric kernels, which tend to overestimate the genetic variance and the heritability. Using mice data, I show that heritabilities from identity-by-state and...Continue Reading

References

Jan 1, 1982·Cytogenetics and Cell Genetics·A G Searle, C V Beechey
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jul 13, 2006·Nature Genetics·William ValdarJonathan Flint
Sep 2, 2008·Genetics·Andrés LegarraJean-Michel Elsen
Feb 14, 2009·Journal of Animal Science·G de Los CamposG J M Rosa
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Sep 30, 2010·Nature Reviews. Genetics·Joseph E PowellMichael E Goddard
Dec 15, 2010·Genetics Research·Andrés LegarraSébastien Fritz
Jul 20, 2011·Genetics Research·Z G VitezicaA Legarra
Nov 9, 2011·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·T H E MeuwissenJ A Woolliams
Nov 2, 2014·Frontiers in Genetics·Gota Morota, Daniel Gianola

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Citations

Oct 1, 2016·Genetics, Selection, Evolution : GSE·Mohammad H FerdosiBruce Tier
Nov 14, 2018·Journal of Animal Science·Elizabeth M van GrevenhofMario P L Calus
Jan 8, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Daniel GianolaDorian J Garrick
Aug 3, 2017·Genetics, Selection, Evolution : GSE·Qianqian ZhangGoutam Sahana
Apr 9, 2020·Journal of Animal Science·Ignacy MisztalAndres Legarra
Apr 15, 2019·Journal of Dairy Science·D J A SantosL Ma
Aug 16, 2016·G3 : Genes - Genomes - Genetics·Daniel GianolaChris-Carolin Schön
May 17, 2017·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·E N FernándezM Baselga
Apr 22, 2017·Genetics, Selection, Evolution : GSE·Nasir MoghaddarJulius H J van der Werf
Mar 12, 2017·Genetics, Selection, Evolution : GSE·Carolina A Garcia-BaccinoRodolfo J C Cantet
Dec 18, 2019·Genetics, Selection, Evolution : GSE·Øyvind NordbøTheo Meuwissen
Nov 21, 2018·Frontiers in Plant Science·Heike MolenaarHans-Peter Piepho
Aug 7, 2019·Genetics·Nicholas SchreckMartin Schlather
Jun 29, 2018·Frontiers in Genetics·Daniel GianolaChris-Carolin Schön
Sep 10, 2020·Frontiers in Genetics·Theo H E MeuwissenJohn A Woolliams
Oct 31, 2020·Journal of Animal Science·Lorena Ferreira BenficaMaria Eugênia Zerlotti Mercadante
May 11, 2018·Genetics·Tao XiangAndres Legarra
Jan 12, 2021·Frontiers in Genetics·Vinícius Silva JunqueiraFernando Flores Cardoso
Mar 1, 2019·G3 : Genes - Genomes - Genetics·Jilun MengNorbert Reinsch
Apr 18, 2021·Genetics·David González-DiéguezZulma G Vitezica
Oct 1, 2019·Genetics·Nicholas SchreckMartin Schlather

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