Comparing Laparoscopic Elective Sigmoid Resection With Conservative Treatment in Improving Quality of Life of Patients With Diverticulitis: The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) Randomized Clinical Trial.

JAMA Surgery
Alexandre SantosVille Sallinen

Abstract

Diverticulitis has a tendency to recur and affect quality of life. To assess whether sigmoid resection is superior to conservative treatment in improving quality of life of patients with recurrent, complicated, or persistent painful diverticulitis. This open-label randomized clinical trial assessed for eligibility 128 patients with recurrent, complicated, or persistent painful diverticulitis in 6 Finnish hospitals from September 29, 2014, to October 10, 2018. Exclusion criteria included age younger than 18 years or older than 75 years; lack of (virtual) colonoscopy or sigmoidoscopy data within 2 years, or presence of cancer, contraindication to laparoscopy, or fistula. Outcomes were assessed using intention-to-treat analysis. A prespecified interim analysis was undertaken when 66 patients had been randomized and their 6-month follow-up was assessable. Data were analyzed from June 2018 to May 2020. Laparoscopic sigmoid resection or conservative treatment. The primary outcome was difference in Gastrointestinal Quality of Life Index (GIQLI) score between randomization and 6 months. Of 128 patients assessed for eligibility, 90 were randomized (28 male [31%]; mean [SD] age, 54.11 [11.9] years; 62 female [69%]; mean [SD] age, 57.13 [...Continue Reading

References

Jan 5, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·C TaftM Sullivan
Jun 3, 2006·Diseases of the Colon and Rectum·Janice RaffertyUNKNOWN Standards Committee of American Society of Colon and Rectal Surgeons
Jun 15, 2006·Annals of Surgery·Jennifer R ChapmanDirk R Larson
Feb 13, 2009·Annals of Surgery·Antonello ForgioneJacques Marescaux
Dec 28, 2011·International Journal of Colorectal Disease·Itai PasternakGian A Melcher
Feb 1, 2012·The British Journal of Surgery·A ChabokUNKNOWN AVOD Study Group
Apr 12, 2013·Diseases of the Colon and Rectum·Wolfgang B GaertnerGenevieve B Melton
Jul 11, 2013·Digestive Surgery·Bryan J M van de WallIvo A M J Broeders
Jan 17, 2014·JAMA Surgery·Scott E RegenbogenArden M Morris
Feb 11, 2014·Diseases of the Colon and Rectum·Daniel FeingoldJanice Frederick Rafferty
Feb 25, 2015·The Journal of Trauma and Acute Care Surgery·Ville J SallinenPanu J Mentula
Aug 26, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Caroline S AndewegHarry van Goor
May 6, 2016·Diseases of the Colon and Rectum·Juha P MaliVille J Sallinen
Aug 2, 2016·World Journal of Emergency Surgery : WJES·Massimo SartelliErnest E Moore
Oct 1, 2016·The British Journal of Surgery·L DanielsUNKNOWN Dutch Diverticular Disease (3D) Collaborative Study Group
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Bryan J M van de WallUNKNOWN DIRECT trial collaborators
Jul 6, 2017·Journal of Clinical Epidemiology·Ravishankar JayadevappaSumedha Chhatre
Jun 27, 2018·Clinics in Colon and Rectal Surgery·Semeret T Munie, Surya P M Nalamati
May 10, 2020·Diseases of the Colon and Rectum·Jason HallUNKNOWN Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons

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Citations

Feb 8, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anne F Peery
May 4, 2021·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·A ChabokV Sallinen
Jun 10, 2021·JAMA Surgery·Arianna BirindelliLucio Taglietti
Jun 10, 2021·JAMA Surgery·Sergio A AcunaTyler R Chesney
Jun 10, 2021·JAMA Surgery·Emma S LumleySaba P Balasubramanian
Jun 10, 2021·JAMA Surgery·Ville SallinenPanu Mentula
Jun 10, 2021·JAMA Surgery·Johannes Kurt SchultzPamela Buchwald
Sep 25, 2021·Langenbeck's Archives of Surgery·Roberto CirocchiRiccardo Nascimbeni

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Methods Mentioned

BETA
lavage

Software Mentioned

Blockrand
Power
R Foundation for Statistical Computing
DIRECT
R

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