Comparing localized and nonlocalized dynamic 31P magnetic resonance spectroscopy in exercising muscle at 7 T.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Martin MeyerspeerEwald Moser

Abstract

By improving spatial and anatomical specificity, localized spectroscopy can enhance the power and accuracy of the quantitative analysis of cellular metabolism and bioenergetics. Localized and nonlocalized dynamic (31)P magnetic resonance spectroscopy using a surface coil was compared during aerobic exercise and recovery of human calf muscle. For localization, a short echo time single-voxel magnetic resonance spectroscopy sequence with adiabatic refocusing (semi-LASER) was applied, enabling the quantification of phosphocreatine, inorganic phosphate, and pH value in a single muscle (medial gastrocnemius) in single shots (T(R) = 6 s). All measurements were performed in a 7 T whole body scanner with a nonmagnetic ergometer. From a series of equal exercise bouts we conclude that: (a) with localization, measured phosphocreatine declines in exercise to a lower value (79 ± 7% cf. 53 ± 10%, P = 0.002), (b) phosphocreatine recovery shows shorter half time (t(1/2) = 34 ± 7 s cf. t(1/2) = 42 ± 7 s, nonsignificant) and initial postexercise phosphocreatine resynthesis rate is significantly higher (32 ± 5 mM/min cf. 17 ± 4 mM/min, P = 0.001) and (c) in contrast to nonlocalized (31)P magnetic resonance spectroscopy, no splitting of the inorgan...Continue Reading

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Citations

Jul 21, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Norman StutzigTobias Siebert
Jun 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Oleksandr KhegaiProdromos Parasoglou
Jan 26, 2017·Analytical Biochemistry·Ladislav ValkovičMartin Krššák
Sep 10, 2014·Medicine and Science in Sports and Exercise·Marc JubeauJulien Gondin
Dec 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marc Jubeau, Julien Gondin
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Feb 20, 2018·The Journal of Physiology·Andreas BossArend Heerschap
Jun 27, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Albrecht Ingo SchmidLadislav Valkovič
Apr 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Prodromos ParasoglouRavinder R Regatte
Jan 3, 2014·Journal of Magnetic Resonance Imaging : JMRI·Elmar LaistlerJean-Christophe Ginefri
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin MeyerspeerArthur W Magill
Oct 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Prodromos ParasoglouRavinder R Regatte
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sigrun GoluchElmar Laistler
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Oct 8, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benjamin RowlandAlexander P Lin
Aug 24, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benjamin C RowlandRichard G Wise
Feb 11, 2020·NMR in Biomedicine·Martin MeyerspeerUNKNOWN Experts' Working Group on 31P MR Spectroscopy of Skeletal Muscle
Jun 13, 2019·Topics in Magnetic Resonance Imaging : TMRI·Sebastian C NiesporekTanja Platt
Feb 26, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fabian NiessMartin Meyerspeer
Aug 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dushyant KumarRavinder Reddy
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Apr 6, 2019·Topics in Magnetic Resonance Imaging : TMRI·Vladimir JurasSiegfried Trattnig
Apr 3, 2021·Scientific Reports·Rajiv G MenonRavinder R Regatte

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Methods Mentioned

BETA
NMR

Software Mentioned

AMARES
jMRUI
MELODIC Independent Component Analysis
Matlab
FMRIB linear image registration tool ( FLIRT )

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