PMID: 8586132Oct 1, 1995Paper

Comparing methods for assessing bronchial responsiveness in children: single step cold air challenge, multiple step cold air challenge, and histamine provocation

The European Respiratory Journal
M ModlM S Zach

Abstract

Cold air challenge (CACh) can be applied by either a single step (SSCACh) or a multiple step (MSCACh) protocol. The interrelationship of the responses of the different protocols has not yet been studied. Furthermore, there is contradictory information on the correlation of cold air challenge responses to the outcome of pharmacological provocations. A single and a multiple step cold air challenge and a histamine provocation were performed in random order on three consecutive days on 28 children and adolescents with bronchial asthma, who were currently symptom- and medication-free. Single step cold air challenge consisted of a 4 min isocapnic hyperventilation of dry, -10 degrees C air; the subjects's response was quantified by the induced change in forced expiratory volume in one second (FEV1). Multiple step cold air challenge consisted of a series of 3 min, cold dry air hyperventilation steps from 20 to 80% of maximal voluntary ventilation (MVV); response was expressed as the provocative dose causing a 10% fall in FEV1 (PD10). Histamine provocation consisted of a series of 2 min inhalations of stepwise increasing histamine concentrations from 0.03 to 8.0 mg.mL-1; response was expressed as the provocative concentration of histami...Continue Reading

Citations

Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W GruberM S Zach
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·K G Nielsen, H Bisgaard
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·K G Nielsen, H Bisgaard
Feb 24, 2005·Treatments in Respiratory Medicine·Kuender D Yang
Apr 25, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Karl P SylvesterAnne Greenough
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Robert S TepperAlkis Togias
May 6, 2004·Medicine and Science in Sports and Exercise·Mona ZeitounOded Bar-Or

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