Comparing MTI randomization procedures to blocked randomization

Statistics in Medicine
Vance W BergerRebecca Agnor

Abstract

Randomization is one of the cornerstones of the randomized clinical trial, and there is no shortage of methods one can use to randomize patients to treatment groups. When deciding which one to use, researchers must bear in mind that not all randomization procedures are equally adept at achieving the objective of randomization, namely, balanced treatment groups. One threat is chronological bias, and permuted blocks randomization does such a good job at controlling chronological bias that it has become the standard randomization procedure in clinical trials. But permuted blocks randomization is especially vulnerable to selection bias, so as a result, the maximum tolerated imbalance (MTI) procedures were proposed as better alternatives. In comparing the procedures, we have somewhat of a false controversy, in that actual practice goes uniformly one way (permuted blocks), whereas scientific arguments go uniformly the other way (MTI procedures). There is no argument in the literature to suggest that the permuted block design is better than or even as good as the MTI procedures, but this dearth is matched by an equivalent one regarding actual trials using the MTI procedures. So the 'controversy', if we are to call it that, pits misgui...Continue Reading

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Citations

Feb 15, 2019·Clinical Trials : Journal of the Society for Clinical Trials·Stéphanie L van der Pas
Apr 28, 2016·Statistics in Medicine·Adam Crisp
Nov 20, 2016·Statistical Methods in Medical Research·Wenle ZhaoZhenning Yu
Apr 19, 2017·Statistics in Medicine·Marcia Viviane RückbeilNicole Heussen
Apr 28, 2016·Statistics in Medicine·Vance W Berger, Rebecca Agnor
Dec 6, 2017·BMC Medical Research Methodology·Ralf-Dieter HilgersNicole Heussen
Jul 5, 2019·BMC Medical Research Methodology·Jody D CiolinoHayley M Belli
May 25, 2021·Contemporary Clinical Trials·Hong-Wei Cai, Xun Zhou
Aug 4, 2021·Healthcare : the Journal of Delivery Science and Innovation·Deborah LaiShuhan He
Aug 18, 2021·BMC Medical Research Methodology·Vance W BergerUNKNOWN Randomization Innovative Design Scientific Working Group

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