Comparing perfusion CT evaluation algorithms for predicting outcome after endovascular treatment in anterior circulation ischaemic stroke

Clinical Radiology
A V KhawS Langner

Abstract

To analyse perfusion CT (PCT) evaluation algorithms for their predictive value for outcome after endovascular therapy (ET) in acute ischaemic stroke. Twenty-six patients were prospectively enrolled to undergo endovascular therapy for moderate to severe [National Institute of Health Stroke Scale (NIHSS) score of ≥5] anterior circulation stroke ≤6 h of onset. PCT datasets were evaluated according to three algorithms: visual mismatch estimate (VME), Alberta Stroke Programme Early CT Score (ASPECTS) perfusion, and quantitative perfusion ratios (QPRs: RCBF, RCBV) of cerebral blood flow (CBF) and volume (CBV). Results were correlated with outcome measures [NIHSS score at discharge, NIHSS score change until discharge (ΔNIHSSA/D), mRS at 90 days (mRS90d)] and compared with a matched control group. Recanalization was achieved in 73%, median NIHSS score decreased from 14 to 5 at discharge. The treatment and control group did not differ by VME and ASPECTS perfusion, nor did VME correlate with any of the three outcome measures. ASPECTS perfusion was not predictive of any outcome measure in the ET group. RCBF and RCBV were associated with ΔNIHSSA/D in controls and, inversely, the ET group, but not with mRS90d. Receiver operating characteris...Continue Reading

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupL Symon
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·J T Lindsay WilsonIan Bone
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
Oct 22, 2005·Annals of Neurology·Mark W ParsonsChristopher R Levi
Feb 9, 2008·Stroke; a Journal of Cerebral Circulation·Masashi TakasawaJean-Claude Baron
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·Wade S SmithIsaac E Silverman
May 24, 2008·AJNR. American Journal of Neuroradiology·A BoseUNKNOWN Penumbra Phase 1 Stroke Trial Investigators
Nov 21, 2009·Stroke; a Journal of Cerebral Circulation·Nishant K MishraKennedy R Lees
Jan 9, 2010·Stroke; a Journal of Cerebral Circulation·Deidre A De SilvaUNKNOWN Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) Investigators
Mar 2, 2010·AJNR. American Journal of Neuroradiology·Y W LuiV Spektor
Jun 12, 2010·Stroke; a Journal of Cerebral Circulation·Carlos CastañoAntoni Dávalos
Oct 12, 2010·Neurology·Kate C YoungBabak S Jahromi
Mar 23, 2012·The New England Journal of Medicine·Mark ParsonsChristopher Levi
Mar 24, 2012·Stroke; a Journal of Cerebral Circulation·Luis San RománAngel Chamorro
Feb 8, 2013·The New England Journal of Medicine·Alfonso CicconeUNKNOWN SYNTHESIS Expansion Investigators
Feb 9, 2013·The New England Journal of Medicine·Joseph P BroderickUNKNOWN Interventional Management of Stroke (IMS) III Investigators
Feb 12, 2013·The New England Journal of Medicine·Chelsea S KidwellUNKNOWN MR RESCUE Investigators
Aug 21, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Amir KheradmandDavid Paydarfar
Jan 18, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·A BivardM Parsons

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Citations

Aug 9, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Anselm AngermaierSoenke Langner

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