PMID: 26320431Sep 1, 2015Paper

Comparing Role of Two Chemotherapy Regimens, CMF and Anthracycline-Based, on Breast Cancer Survival in the Eastern Mediterranean Region and Asia by Multivariate Mixed Effects Models: a Meta-Analysis

Asian Pacific Journal of Cancer Prevention : APJCP
Saeed GhanbariNajaf Zare

Abstract

To assess the role of two adjuvant chemotherapy regimens, anthracycline-based and CMF on disease free survival and overall survival breast cancer patients by meta-analysis approach in Eastern Mediterranean and Asian countries to determine which is more effective and evaluate the appropriateness and efficiency of two different proposed statistical models. Survival curves were digitized and the survival proportions and times were extracted and modeled to appropriate covariates by two multivariate mixed effects models. Studies which reported disease free survival and overall survival curves for anthracycline-based or CMF as adjuvant chemotherapy that were published in English in the Eastern Mediterranean region and Asia were included in this systematic review. The two transformations of survival probabilities (Ln (-Ln(S)) and Ln(S/ (1-S))) as dependent variables were modeled by a multivariate mixed model to same covariates in order to have precise estimations with high power and appropriate interpretation of covariate effects. The analysis was carried out with SAS Proc MIXED and STATA software. A total of 32 studies from the published literature were analysed, covering 4,092 patients who received anthracycline-based and 2,501 trea...Continue Reading

References

Jun 30, 2006·Contemporary Clinical Trials·Rebecca DerSimonian, Raghu Kacker
Aug 25, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinichi WakamatsuKazuo Tamura
Jun 27, 2007·The Breast Journal·Seyed Mohsen MousaviMandana Ebrahimi
Jan 16, 2008·Journal of Zhejiang University. Science. B·Jin Zhang, Yan Liu
Feb 19, 2008·Breast Cancer Research and Treatment·Lian-Fang LiZhi-Ming Shao
May 10, 2008·Statistics in Medicine·Lidia R ArendsTheo Stijnen
Apr 9, 2009·Radiation Oncology·Nabil IsmailiHassan Errihani
Jan 1, 2009·Breast Care·Alexander KatalinicAnnika Waldmann
Jan 5, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L YaoY Xie
Oct 18, 2011·International Archives of Medicine·Hamza AbbasBasem Gamal
Apr 25, 2012·Journal of Cancer Research and Clinical Oncology·Huizhe WuMinjie Wei
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Najaf ZareAbass Rezaianzadeh
Mar 12, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S ChenZ M Shao
May 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ajay GogiaDaya Nand Sharma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.