Comparing single and repeated dosimetry data for perfluorooctane sulfonate in rats

Toxicology Letters
Leona A Harris, Hugh A Barton

Abstract

Perfluorooctane sulfonate (PFOS) is a member of a class of perfluorinated chemicals used in a variety of consumer and industrial applications because of their oleophobic and hydrophobic properties. It has been shown to cause toxicity in adult and developing laboratory animals. Because PFOS has also been shown to be widely distributed throughout the environment, there have been concerns about its potential health risk to humans. Limited pharmacokinetic data for PFOS are available in rodents and humans, while epidemiological studies of workers and extensive toxicity studies in rodents have been performed. The existing pharmacokinetic and toxicity database in rodents can be useful in the cross-species extrapolations needed to evaluate and interpret internal dosimetry in humans. A mathematical model that describes the disposition of PFOS in adult rats following intravenous, oral, and chronic dietary exposures was developed to gain a better understanding of the pharmacokinetics of PFOS and to determine whether single-dose kinetics are predictive of repeated-dose kinetics. In order to characterize existing time-course data, time-dependent and concentration-dependent changes in the pharmacokinetic parameters for urinary and biliary cl...Continue Reading

References

Oct 1, 1983·Journal of Pharmaceutical Sciences·L E Gerlowski, R K Jain
Jul 1, 1997·Toxicology and Industrial Health·R P BrownR P Beliles
May 12, 2001·Environmental Science & Technology·J P Giesy, K Kannan
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew M SeacatJohn L Butenhoff
Dec 31, 2002·Toxicology·Andrew M SeacatJohn L Butenhoff
Jun 25, 2003·The Journal of Toxicological Sciences·Naomi Kudo, Yoichi Kawashima
Jul 30, 2003·Clinical Pharmacokinetics·Ivan Nestorov
Nov 1, 2003·Environmental Toxicology and Chemistry·Paul D JonesJohn P Giesy
Jun 24, 2004·Risk Analysis : an Official Publication of the Society for Risk Analysis·Justin G Teeguarden, Hugh A Barton
Jul 9, 2004·Toxicology and Applied Pharmacology·Christopher LauJohn M Rogers
May 4, 2005·Environmental Health Perspectives·Geary W OlsenJeffrey H Mandel
Jun 30, 2005·Environmental Science & Technology·Stephen T WashburnAnnette M Shipp
Apr 24, 2007·Annals of Epidemiology·Bruce H Alexander, Geary W Olsen
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
Apr 19, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·David TrudelKonrad Hungerbühler
May 8, 2008·American Journal of Epidemiology·Chunyuan FeiJørn Olsen
Jan 9, 2009·Journal of Pharmacokinetics and Pharmacodynamics·John F WambaughR Woodrow Setzer

❮ Previous
Next ❯

Citations

Nov 14, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Inchio LouHugh A Barton
Jun 26, 2013·Food Chemistry·E D van AsseltH J van der Fels-Klerx
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sook-Jin KimHea-Young Cho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.