Comparing Spirometric Reference Values From Childhood to Old Age Estimated by LMS and Linear Regression Models.

Archivos de bronconeumología
David Martínez-BriseñoRogelio Pérez-Padilla

Abstract

Proper reference values for lung function testing are essential for achieving adequate interpretations. The LMS procedure (lambda, mu, sigma) permits continuous analyses of entire populations avoiding gaps in the transition between childhood and adulthood. It also allows more precise calculations of average values, dispersion, and 5th percentiles, which are usually considered the lower limit of normality. The objective of this study was to compare our results fitted with the LMS method with standard multiple linear regression, and with those from international Global Lung Function Initiative (GLI) equations. Data from 9835 healthy residents of the metropolitan area of Mexico City aged 8-80 years were compiled from several studies: EMPECE, PLATINO, adult Mexican workers and two unpublished studies. The LMS procedure and multiple linear regression models were fit to obtain reference equations using R software. Residuals from the LMS models had a median closer to zero, and smaller dispersion than those from the linear model, but differences although statistically significant were very small and of questionable practical relevance. For example, for females and ln(FEV1), median residual was -0.001 with p25 of -0.08 and p75 of 0.08 f...Continue Reading

References

Jan 1, 1988·American Journal of Physical Anthropology·L P GreksaL Paredes-Fernández
Nov 1, 1980·Respiration Physiology·A J Lechner, N Banchero
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Nov 1, 1993·Annals of Human Biology·S L Malik, A K Pandey
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Aug 6, 2002·Respiratory Physiology & Neurobiology·Adrian P HavrykKeith R Burgess
Feb 5, 2003·Pediatric Pulmonology·Rogelio Pérez-PadillaGustavo Olaiz
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Sep 2, 2006·Archivos de bronconeumología·Rogelio Pérez-PadillaAna María B Menezes
Oct 18, 2007·Archivos de bronconeumología·Rogelio Pérez-PadillaUNKNOWN grupo PLATINO
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Sanja StanojevicTim J Cole
Dec 25, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Cristina PadezBarry Bogin
Apr 23, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert M MalinaBertis B Little
Mar 16, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bruce R ThompsonUNKNOWN ANZSRS Reference Ranges Working Party
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Oct 22, 2013·PloS One·David Martínez-BriseñoRogelio Pérez-Padilla
Dec 18, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sanja StanojevicDiana Bilton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.