Comparing the effect of office hysteroscopy with endometrial scratch versus office hysteroscopy on intrauterine insemination outcome: a randomized controlled trial

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Waleed El-KhayatWaleed Saber

Abstract

To evaluate the role of endometrial injury in the cycle preceding ovarian stimulation for intrauterine insemination (IUI) cycle on the clinical pregnancy rate. This was a prospective randomized controlled trial which included three hundred and thirty two infertile women with an indication for IUI. The subjects were randomly divided into two groups. The intervention group (group A) (n=166) subjects underwent office hysteroscopy with endometrial injury using grasping forceps with teeth, while the control group (group B) (n=166) subjects underwent office hysteroscopy alone without endometrial injury. Primary outcome was clinical pregnancy rate. There were no significant differences in baseline or clinical characteristics between the groups. There were no significant differences in clinical pregnancy rate [13.8% (23/166) versus 12% (20/166); RR 1.15 (95% CI 0.66-2.01), p=0.62]. The abortion rate [4.3% (1/23) versus 15% (3/20); RR 0.29 (95% CI 0.03-2.57), p=0.27], the multiple pregnancy rate [13% (3/23) versus 15% (3/20); RR 0.87 (95% CI 0.20-3.83), p=0.85] and the live birth rate [13.6% (22/166) versus 10.4% (17/166); RR 1.28 (95% CI 0.71-2.32), p=0.42]. There is no evidence of significant difference on the clinical pregnancy rate ...Continue Reading

Associated Clinical Trials

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Citations

Feb 6, 2016·American Journal of Reproductive Immunology : AJRI·Arsène MekinianMarie Bornes
Jun 4, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mehmet Murat SevalCem Atabekoğlu
Mar 25, 2016·Human Reproduction Update·Attilio Di Spiezio SardoGiuseppe Bifulco
Jul 25, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Cem CelikAbdulaziz Gul
Jun 15, 2016·The Cochrane Database of Systematic Reviews·Sarah F LensenCindy Farquhar
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jan BosteelsBen Willem J Mol
Nov 6, 2018·Human Reproduction Update·Chen Sar-Shalom NahshonMartha Dirnfeld
Apr 17, 2019·The Cochrane Database of Systematic Reviews·Mohan S KamathSesh Kamal Sunkara
Jun 4, 2016·Current Opinion in Obstetrics & Gynecology·Xavier SantamariaCarlos Simón
Mar 19, 2021·The Cochrane Database of Systematic Reviews·Bich Ngoc BuiFrank J Broekmans
Oct 2, 2017·Journal of Gynecology Obstetrics and Human Reproduction·G C SenocakB Borekci
Nov 18, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ahmed M MagedEman A Hussein

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