Comparing the Effects of Bupropion and Escitalopram on Excessive Internet Game Play in Patients with Major Depressive Disorder

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Beomwoo NamDoug Hyun Han

Abstract

Several studies have suggested the efficacy of bupropion and escitalopram on reducing the excessive internet game play. We hypothesized that both bupropion and escitalopram would be effective on reducing the severity of depressive symptoms and internet gaming disorder (IGD) symptoms in patients with both major depressive disorder and IGD. However, the changes in brain connectivity between the default mode network (DMN) and the salience network were different between bupropion and escitalopram due to their different pharmacodynamics. This study was designed as a 12-week double blind prospective trial. Thirty patients were recruited for this research (15 bupropion group+15 escitalopram group). To assess the differential functional connectivity (FC) between the hubs of the DMN and the salience network, we selected 12 regions from the automated anatomical labeling in PickAtals software. After drug treatment, the depressive symptoms and IGD symptoms in both groups were improved. Impulsivity and attentional symptoms in the bupropion group were significantly decreased, compared to the escitalopram group. After treatment, FC within only the DMN in escitalopram decreased while FC between DMN and salience network in bupropion group decre...Continue Reading

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Citations

Nov 2, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Kukju Kweon, Hyo-Won Kim
Sep 24, 2019·Expert Review of Neurotherapeutics·Kristyn ZajacRocio Chang
Apr 24, 2018·The Cochrane Database of Systematic Reviews·Giovanni OstuzziMatthew Hotopf
Apr 12, 2019·Frontiers in Psychology·Sebastiano Costa, Daria J Kuss
May 2, 2019·Reproduction, Fertility, and Development·Eliane S A M SanchesMaria J S Salles
May 7, 2019·Expert Opinion on Pharmacotherapy·Krzysztof ŁukawskiStanisław J Czuczwar
May 4, 2020·Journal of Behavioral Addictions·Martina GoslarAnton-Rupert Laireiter

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Software Mentioned

SPSS Statistics
MPRAGE
PickAtals

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