Comparing the efficacy and safety of laparoscopic and robotic adrenalectomy: a meta-analysis and trial sequential analysis.

Langenbeck's Archives of Surgery
Konstantinos PerivoliotisGeorge Tzovaras

Abstract

A systematic literature review and a meta-analysis were designed and conducted, in order to provide an up-to-date comparison of the robotic (RA) and laparoscopic (LA) adrenalectomy in terms of perioperative efficacy and safety. The present meta-analysis was completed in accordance with the guidelines provided by the PRISMA study group and the Cochrane Handbook for Systematic Reviews of Interventions. The electronic scholar databases (Medline, Web of Science, Scopus) were screened. For the reduction of type I errors, a trial sequential analysis (TSA) was performed. Overall, 21 studies and 2997 patients were included in this study. RA was associated with a significantly lower open conversion rate (OR: 1.79; 95%CI: 1.10, 2.92) and length of hospitalization (LOS WMD: 0.52; 95%CI: 0.2, 0.84). Marginal results regarding blood loss were recorded (WMD: 2.02; 95%CI: 0.0, 4.03). TSA could not validate the superiority of RA in open conversion rate and blood loss. LA and RA were similar in terms of operative duration (P = 0.18) and positive margin (P = 0.81), complications (P = 0.94) and mortality rate (P = 0.45). Even though RA and LA were equivalent regarding perioperative safety, RA was associated with a favorable LOS.

References

Oct 1, 1992·The New England Journal of Medicine·M GagnerE Bolté
Jun 11, 1999·The British Journal of Surgery·N E Dudley, B J Harrison
Oct 19, 2004·World Journal of Surgery·Laurent BrunaudPatrick Boissel
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Dec 18, 2007·Journal of Clinical Epidemiology·Jørn WetterslevChristian Gluud
Dec 2, 2008·Surgery·Laurent BrunaudLaurent Bresler
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
May 21, 2010·Journal of Endourology·Aaron T LudwigTerry C Lairmore
Aug 18, 2010·Archives of Surgery·Eren BerberAllan Siperstein
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Mar 8, 2012·Annals of Surgical Oncology·Orhan AgcaogluEren Berber
Mar 21, 2012·Archives of Surgery·Orhan AgcaogluEren Berber
Sep 8, 2012·Surgical Endoscopy·Karen Pineda-SolísMartin J Heslin
Oct 2, 2012·The British Journal of Surgery·V A ConstantinidesF F Palazzo
Oct 18, 2012·Surgical Endoscopy·Erol AksoyEren Berber
Apr 30, 2013·Langenbeck's Archives of Surgery·Guido Alberto Massimo TiberioStefano Maria Giulini
May 4, 2013·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Ji Young YouHoon Yub Kim
Jul 19, 2013·Annals of Surgical Oncology·Shamil AliyevEren Berber
May 17, 2014·European Urology·Luis Felipe BrandaoJihad Kaouk
Jan 20, 2015·Journal of Minimal Access Surgery·Mrinal PahwaAjay Sharma
Mar 5, 2016·World Journal of Surgery·Terry C LairmoreSamuel K Snyder
Oct 14, 2016·BMJ : British Medical Journal·Jonathan Ac SterneJulian Pt Higgins
Jan 4, 2017·International Journal of Surgery·Konstantinos P EconomopoulosMelanie L Richards
Apr 20, 2017·Updates in Surgery·Giovanni AlemannoAndrea Valeri
May 13, 2017·Updates in Surgery·C Nomine-CriquiL Brunaud
May 16, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshio TakagiKazunari Tanabe
Jun 22, 2017·World Journal of Surgery·Patrick HegerMarkus K Diener
Jul 21, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Jennifer ColvinEren Berber
Oct 13, 2017·World Journal of Surgery·Natalie A CalcateraRichard A Prinz
Nov 7, 2017·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Hani J MarcusAra Darzi
Feb 2, 2018·Journal of Robotic Surgery·Zuliang FengCarmen C Solórzano
Apr 27, 2018·Journal of Robotic Surgery·Sarah SamreenJoseph A Blansfield
Aug 23, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Brian C RuhleRaymon H Grogan

❮ Previous
Next ❯

Citations

Nov 12, 2020·Updates in Surgery·Gabriele Materazzi, Leonardo Rossi
Aug 28, 2021·Biomedicines·Giuseppe CavallaroClaudio Letizia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.