Comparing the eighth and the seventh editions of the American Joint Committee on Cancer staging system and the Brigham and Women's Hospital alternative staging system for cutaneous squamous cell carcinoma: Implications for clinical practice

Journal of the American Academy of Dermatology
Javier CañuetoConcepción Román-Curto

Abstract

The new eighth edition of the American Joint Committee on Cancer staging system (AJCC-8) incorporates changes regarding cutaneous squamous cell carcinoma (CSCC). We aimed to compare the AJCC-8 staging system with the previous seventh edition of the AJCC staging system (AJCC-7) and the Brigham and Women's Hospital (BWH) alternative staging system to identify their usefulness and the utility of their risk factors in defining prognostic groups in CSCC. A series of 186 CSCCs of the head and neck were retrospectively collected. All 3 staging systems were compared from the standpoint of their ability to predict poor prognosis. Binary logistic regression models were built to determine which risk factors were most relevant. Poor prognosis was mainly associated with stage T2 of the AJCC-7, with stages T2b/T3 of the BWH system, and with stage T3 of the AJCC-8. The AJCC-8 and the BWH staging systems displayed overlap with each another in predicting poor prognosis, and both were superior to the AJCC-7. The new risk factors incorporated into the AJCC-8 and the poor degree of differentiation were independently associated with poor outcome. Retrospective study and few cases with bone invasion. The AJCC-8 is more distinctive, monotonous, and h...Continue Reading

Citations

Oct 1, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Antonio Tejera-VaquerizoOnofre Sanmartín
Feb 18, 2020·Oral Oncology·Kristin BibeeDan P Zandberg
Feb 24, 2021·Plastic and Reconstructive Surgery·Thomas J KnackstedtDavid R Crowe
Apr 13, 2021·Experimental Dermatology·Gina Pacella, Brian C Capell
Sep 19, 2021·International Wound Journal·Ahmed K MousaSherif E Sayed
Oct 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C DessiniotiA J Stratigos
May 4, 2020·Actas dermo-sifiliográficas·J CañuetoO Sanmartin
Nov 20, 2021·Cancer Medicine·Vishal A PatelAnokhi Jambusaria-Pahlajani

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Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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