Aug 27, 2011

Comparing the influence of dopamine D₂ polymorphisms and plasma drug concentrations on the clinical response to risperidone

Journal of Clinical Psychopharmacology
Norio Yasui-FurukoriS Kaneko

Abstract

Although several studies have reported that dopamine D₂ receptor (DRD2) polymorphisms affect the therapeutic efficacy of antipsychotics, other studies have suggested that the plasma drug concentration is related to the clinical response. Currently, there are no definitive data regarding which factor has greater clinical significance. Sixty patients with acute exacerbations of schizophrenia received 6 mg/d of risperidone for 4 weeks. Clinical evaluations using the Brief Psychiatric Rating Scale and the Udvalg for Klinicke Undersøgelser Side Effect Rating Scale were performed before and after administration of risperidone. TaqI A and -141C Ins/Del polymorphisms were determined, and the plasma concentrations of risperidone and 9-hydroxyrisperidone were measured. The TaqI A polymorphism had no effect on therapeutic efficacy, but the -141C Ins/Del polymorphism was associated with an improvement in positive symptoms. In addition, the plasma concentration of the active moiety (risperidone plus 9-hydroxyrisperidone) correlated with the improvement in the total Brief Psychiatric Rating Scale score as well as with positive symptoms. Although there were no associations between DRD2 polymorphisms and psychic adverse effects, the plasma dru...Continue Reading

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Mentioned in this Paper

Antipsychotic Effect
Neurobehavioral Manifestations
Response to Risperidone
Schizophrenia
Paliperidone
Dopamine D2 Receptor
Adverse Effects
Antipsychotic Agents
Isoxazoles
Dopamine Measurement

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