Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)

International Journal of Cancer. Journal International Du Cancer
Roosmarijn LuttmerC J L M Meijer

Abstract

Recently, DNA methylation analysis of FAM19A4 in cervical scrapes has been shown to adequately detect high-grade cervical intraepithelial neoplasia and cervical cancer (≥ CIN3) in high-risk HPV (hrHPV)-positive women. Here, we compared the clinical performance of FAM19A4 methylation analysis to cytology and HPV16/18 genotyping, separately and in combination, for ≥ CIN3 detection in hrHPV-positive women participating in a prospective observational multi-center cohort study. The study population comprised hrHPV-positive women aged 18-66 years, visiting a gynecological outpatient clinic. From these women, cervical scrapes and colposcopy-directed biopsies (for histological confirmation) were obtained. Cervical scrapes were analyzed for FAM19A4 gene promoter methylation, cytology and HPV16/18 genotyping. Methylation analysis was performed by quantitative methylation-specific PCR (qMSP). Sensitivities and specificities for ≥ CIN3 were compared between tests. Stratified analyses were performed for variables that potentially influence marker performance. Of all 508 hrHPV-positive women, the sensitivities for ≥ CIN3 of cytology, FAM19A4 methylation analysis, and cytology combined with HPV16/18 genotyping were 85.6, 75.6 and 92.2%, respe...Continue Reading

References

Apr 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A G Ostör
Feb 12, 1998·The New England Journal of Medicine·G Y HoR D Burk
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Jan 25, 2003·American Journal of Epidemiology·Rachel L WinerLaura A Koutsky
Apr 11, 2003·Statistics in Medicine·Nian-Sheng TangIvan Siu Fung Chan
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cornelia L TrimbleDrew Pardoll
Feb 4, 2006·Journal of Clinical Microbiology·Markus SchmittTim Waterboer
Apr 6, 2006·International Journal of Cancer. Journal International Du Cancer·Jack CuzickThomas Iftner
Oct 19, 2007·The New England Journal of Medicine·Pontus NauclerJoakim Dillner
Nov 1, 2008·International Journal of Cancer. Journal International Du Cancer·Chris J L M MeijerPeter J F Snijders
Aug 8, 2009·The Journal of Pathology·Renée M OvermeerRenske D M Steenbergen
Jun 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ralph P InsingaUNKNOWN FUTURE I Investigators
Dec 31, 2010·International Journal of Cancer. Journal International Du Cancer·Renée M OvermeerRenske D M Steenbergen
Mar 11, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Albertus T HesselinkPeter J F Snijders
Mar 15, 2011·International Journal of Cancer. Journal International Du Cancer·Dorien C RijkaartChris J L M Meijer
Jul 29, 2011·International Journal of Cancer. Journal International Du Cancer·J J H EijsinkG B A Wisman
Sep 10, 2011·American Journal of Obstetrics and Gynecology·Ina H BenoyChristophe E Depuydt
Oct 25, 2011·International Journal of Cancer. Journal International Du Cancer·Mariska BierkensRenske D M Steenbergen
Oct 24, 2012·Obstetrics and Gynecology·Vicki B BenardMona Saraiya
Jan 10, 2013·Current Opinion in Obstetrics & Gynecology·Joakim Dillner
Mar 5, 2013·International Journal of Cancer. Journal International Du Cancer·Mariska BierkensRenske D M Steenbergen
Mar 27, 2013·Journal of Lower Genital Tract Disease·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
May 3, 2013·Obstetrics and Gynecology·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
Jun 5, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Maaike G DijkstraJohannes Berkhof
Jan 1, 2014·American Journal of Obstetrics and Gynecology·Karolina LouvantoAlex Ferenczy
Jan 3, 2014·BioMed Research International·Maria Lina TorneselloFranco M Buonaguro
Jan 30, 2014·International Journal of Cancer. Journal International Du Cancer·A T HesselinkP J F Snijders
May 3, 2014·Obstetrics and Gynecology·Shayna N ConnerMethodius G Tuuli
May 24, 2014·Nature Reviews. Cancer·Renske D M SteenbergenChris J L M Meijer
Jun 20, 2014·Obstetrics and Gynecology·Nora DanhofBen Mol
Jun 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lise M A De StrooperDaniëlle A M Heideman
Jun 28, 2014·The Journal of Community and Supportive Oncology·Jame Abraham, Mark Stenger
Oct 5, 2014·Journal of Clinical Pathology·Lise M A De StrooperChris J L M Meijer

❮ Previous
Next ❯

Citations

Jan 30, 2016·Genome Medicine·Naoko Hattori, Toshikazu Ushijima
May 7, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Roosmarijn LuttmerChris J L M Meijer
Sep 7, 2016·Expert Review of Anticancer Therapy·Renée Mf EbischWillem Jg Melchers
Jul 28, 2016·Expert Review of Molecular Diagnostics·Roosmarijn LuttmerChris J L M Meijer
Apr 18, 2018·International Journal of Cancer. Journal International Du Cancer·Lise M A De StrooperDaniëlle A M Heideman
Aug 7, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Wina VerlaatG Bea A Wisman
Apr 17, 2018·Journal of the National Cancer Institute·Kai YuMark Schiffman
Aug 12, 2018·International Journal of Cancer. Journal International Du Cancer·Annemiek LeemanWim G V Quint
Jun 27, 2018·International Journal of Cancer. Journal International Du Cancer·Remila RezhakeFang-Hui Zhao
Sep 28, 2018·International Journal of Cancer. Journal International Du Cancer·Robert W van LeeuwenG Bea A Wisman
Jan 14, 2019·Molecular Genetics & Genomic Medicine·Chao FangKai-Ming Duan
Apr 9, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Iris BabionRenske D M Steenbergen
May 7, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cecile D LahiriLisa Flowers
Aug 2, 2019·Expert Review of Molecular Diagnostics·Kathryn A KundrodRebecca Richards-Kortum
Aug 8, 2019·International Journal of Cancer. Journal International Du Cancer·Frederique J VinkDaniëlle A M Heideman
Jul 12, 2017·AIDS·Marjolein Van ZummerenChris J L M Meijer
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria PanagopoulouEkaterini Chatzaki
Jun 1, 2018·International Journal of Genomics·Chunyang FengTianmin Xu
Oct 3, 2020·International Journal of Cancer. Journal International Du Cancer·Arianis Tatiana RamírezUNKNOWN ASC-US-COL Trial Group
Dec 11, 2020·International Journal of Cancer. Journal International Du Cancer·Na LiG Bea A Wisman
Sep 7, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rachael AdcockUNKNOWN New Mexico HPV Pap Registry Steering Committee
Jun 12, 2019·Gynecologic Oncology·Stèfanie DickDaniëlle A M Heideman
Apr 14, 2021·Scientific Reports·Severien Van KeerAlex Vorsters
Sep 24, 2021·Expert Review of Proteomics·Coşkun GüzelRainer Bischoff
Mar 20, 2019·Acta Cytologica·Andrea D OlivasRicardo R Lastra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Roosmarijn LuttmerC J L M Meijer
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Anne SzarewskiJack Cuzick
International Journal of Cancer. Journal International Du Cancer
Renee M OvermeerRenske D M Steenbergen
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Mark SchiffmanRobert D Burk
© 2021 Meta ULC. All rights reserved