Comparing the protective effects of ciprofloxacin, moxifloxacin and levofloxacin in mice with lipopolysaccharide-induced acute lung injuries

Respirology : Official Journal of the Asian Pacific Society of Respirology
Heng-Ching HuangYin-Ching Chuang

Abstract

Ciprofloxacin, moxifloxacin and levofloxacin are recognized immunomodulators. Their effects in acute lung injuries have not been tested. This study compared the immunoprotective effects of these agents in mice with lung injuries induced by LPS by measuring the cytokine profiles in the injured lung and the associated mortality. The development of lung injury and mortality was compared in mice pretreated with either ciprofloxacin, levofloxacin, moxifloxacin or saline (control group) after the intratracheal administration of LPS. BALF and serum were collected at 1, 3 and 6 h to measure the concentrations of tumour necrosis factor-alpha (TNF-alpha), IL-1beta, IL-6, IL-10 and macrophage inflammatory protein-2 (MIP-2) using enzyme-linked immunoassay. Levels of TNF-alpha, IL-1beta and MIP-2 in the BAL of the ciprofloxacin group were significantly lower compared with those of controls (all P < 0.0083) at 3 and 6 h after LPS challenge. There were no significant differences in the levels of these cytokines in the moxifloxacin and levofloxacin groups compared with controls. Overall, the 96-h survival for the mice pretreated with ciprofloxacin, but not for those pretreated with moxifloxacin or levofloxacin, was significantly greater than t...Continue Reading

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Citations

Apr 9, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin R J Kolb, Ian Yang
Oct 14, 2010·Experimental Lung Research·Yoshitomo MorinagaShimeru Kamihira
Mar 26, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shyh-Ren ChiangYin-Ching Chuang
Jan 21, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·E J GrowcottK H Banner
Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed M NaglahAtef Kalmouch
Sep 21, 2016·Antimicrobial Agents and Chemotherapy·Yoav GalChanoch Kronman
Mar 5, 2019·Chemical Research in Toxicology·Seyyede Araste Aldaghi, Razieh Jalal
May 29, 2009·British Journal of Anaesthesia·N R Webster, H F Galley
Oct 8, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Andrea SauerChristian Bode

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