Comparing two methods for assessment of perfusion-diffusion mismatch in a rodent model of ischaemic stroke: a pilot study

The British Journal of Radiology
Feng ChenYicheng Ni

Abstract

This stroke experiment was designed to define the mismatch between perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) in MRI by applying early or instantly acquired PWI. Eight rats were induced with stroke through photothrombotic occlusion of the middle cerebral artery and scanned serially between 1 h and day 3 after induction using DWI and PWI with a 1.5 T MR scanner. The relative lesion volumes (rLV) on MRI and triphenyl tetrazolium chloride-stained specimens were defined as the proportion of lesion volume over brain volume. Discrepancies in the rLV between PWI- and DWI-derived apparent diffusion coefficient (ADC) maps were expressed by subtraction of the ADC from PWI, resulting in three possible patterns: (i) (PWI-ADC > 10% of PWI) denoting a mismatch; (ii) (-(10% of PWI) <or= PWI-ADC <or= 10% of PWI) denoting a match; and (iii) (PWI-ADC < -(10% of PWI)) denoting a reverse mismatch. The differences were compared with the minuend being either early PWI (ePWI) or instant PWI (iPWI) and the subtrahend being instant ADC (iADC). The occurrence and evolution of PWI-ADC patterns were analysed. Over time, PWI-ADC discrepancies evolved from mismatch, through to match, to reversed mismatch. The PWI-ADC mismatch stil...Continue Reading

References

Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupL Symon
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Hoehn-BerlageK A Hossmann
Aug 26, 1998·European Journal of Pharmacology·H TakamatsuK Umemura
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·T Neumann-HaefelinH J Freund
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·D G DarbyS M Davis
Jun 23, 2000·European Journal of Pharmacology·H TakamatsuK Umemura
Feb 15, 2001·Current Opinion in Neurology·O TouzaniE T MacKenzie
May 19, 2001·Magnetic Resonance Imaging·F PillekampK Hossmann
Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·M HoehnB van der Sanden
Aug 23, 2002·Experimental Brain Research·Hiroyuki TakamatsuKazuo Umemura
Oct 2, 2002·Radiology·Claus Z SimonsenLeif Østergaard
Jun 7, 2003·Stroke; a Journal of Cerebral Circulation·Yueh Z LeeWeili Lin
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Shelagh B CouttsAndrew M Demchuk
Sep 13, 2003·Stroke; a Journal of Cerebral Circulation·Steven Warach
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Ken S ButcherGeoffrey Donnan
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
Dec 25, 2003·Cerebrovascular Diseases·Marc Fisher
Jan 20, 2004·Cerebrovascular Diseases·Stephen M Davis, Geoffrey A Donnan
Feb 3, 2004·Annals of Neurology·Xiangjun MengTimothy Q Duong
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bernhard Schaller, Rudolf Graf
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
May 26, 2005·Stroke; a Journal of Cerebral Circulation·K S ButcherUNKNOWN EPITHET Investigators
Jul 26, 2005·Stroke; a Journal of Cerebral Circulation·Juergen BardutzkyMarc Fisher

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Citations

May 3, 2011·World Journal of Radiology·Feng Chen
Apr 24, 2009·Der Radiologe·C RothW Reith
Oct 2, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasuhiro Suzuki
Oct 22, 2011·Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc·A HelmsH Whelan

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