Comparison among patients≥75 years having percutaneous coronary angioplasty using drug-eluting stents versus bare metal stents

The American Journal of Cardiology
Fabio MangiacapraGermano Di Sciascio

Abstract

Limited data are available on long-term efficacy and safety of drug-eluting stents (DES) in elderly patients who underwent PCI. A total of 635 consecutive patients aged ≥75 years who underwent PCI were enrolled at 2 European centers. Of these, 170 patients received at least 1 DES, whereas 465 patients received bare metal stent (BMS) only. Primary end point was the incidence of net adverse clinical events (NACE), defined as the occurrence of ischemic events or bleeding events, and was compared at a median follow-up of 31.2 months. Clinical follow-up information was available in 593 patients (93.4%). The duration of dual antiplatelet therapy was 12.3±5.1 months in the DES group and 3.8±7.4 months in the BMS group. The Kaplan-Meier estimate of NACE at 5 years was significantly lower in DES-treated patients (40.5%) than in BMS-treated patients (55.7%; p=0.009). This benefit was driven by a significant reduction in myocardial infarction (8.6% vs 16.6%; p=0.038) and target vessel revascularization rates (7.9% vs 21.9%; p=0.003) in the DES group, with no significant increase in the incidence of bleeding events (13.8% vs 12.2%; p=0.882). These results were confirmed at propensity score-adjusted Cox proportional hazard analysis. In conc...Continue Reading

References

Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Oct 25, 2006·Circulation·Young-Hak KimUNKNOWN Long-DES-II Study Investigators
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Aug 11, 2007·International Journal of Cardiology·Kevin R BaineyUNKNOWN APPROACH investigators
Jan 9, 2008·Journal of the American Geriatrics Society·Andreas W SchoenenbergerUNKNOWN Acute Myocardial Infarction in Switzerland Plus Investigators
Nov 10, 2010·The American Journal of Cardiology·Jin M ChengUNKNOWN Interventional Cardiologists of Thoraxcenter (2000-2009)
Jul 1, 2011·Clinical Cardiology·Michael P ThomasUNKNOWN Blue Cross Blue Shield of Michigan Cardiovascular Consortium
Jan 10, 2012·Journal of the American College of Cardiology·Tracy Y WangJohn S Rumsfeld
Jun 20, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Milena Soriano MarcolinoEric Boersma
Sep 14, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gjin NdrepepaAdnan Kastrati
Dec 1, 2012·Global Heart·Kristian ThygesenHarvey D White

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