Comparison among probabilistic neural network, support vector machine and logistic regression for evaluating the effect of subthalamic stimulation in Parkinson disease on ground reaction force during gait

Journal of Biomechanics
A M S MunizJ Nadal

Abstract

Deep brain stimulation of the subthalamic nucleus (DBS-STN) is an approved treatment for advanced Parkinson disease (PD) patients; however, there is a need to further evaluate its effect on gait. This study compares logistic regression (LR), probabilistic neural network (PNN) and support vector machine (SVM) classifiers for discriminating between normal and PD subjects in assessing the effects of DBS-STN on ground reaction force (GRF) with and without medication. Gait analysis of 45 subjects (30 normal and 15 PD subjects who underwent bilateral DBS-STN) was performed. PD subjects were assessed under four test conditions: without treatment (mof-sof), with stimulation alone (mof-son), with medication alone (mon-sof), and with medication and stimulation (mon-son). Principal component (PC) analysis was applied to the three components of GRF separately, where six PC scores from vertical, one from anterior-posterior and one from medial-lateral were chosen by the broken stick test. Stepwise LR analysis employed the first two and fifth vertical PC scores as input variables. Using the bootstrap approach to compare model performances for classifying GRF patterns from normal and untreated PD subjects, the first three and the fifth vertica...Continue Reading

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Citations

Jan 1, 2014·Gait & Posture·Ulrich DillmannAlfred K Louis
Sep 23, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tetsuya Iidaka
Jun 19, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Andre AndradeHans-Joachim Menzel
Apr 6, 2019·Journal of Medical Systems·Nuno Ferrete RibeiroCristina P Santos
Nov 28, 2013·PLoS Computational Biology·Lucas TheisMatthias Bethge
Oct 23, 2013·Journal of Applied Biomechanics·André G P AndradeLuci F Teixeira-Salmela
Jan 13, 2019·Sensors·Nicolas KhourySamer Mohammed
Nov 14, 2018·Biomedical Engineering Online·A H ButtF Cavallo
Sep 27, 2018·Frontiers in Computational Neuroscience·Ritesh A RamdhaniBrian H Kopell
Jan 20, 2021·Medical Engineering & Physics·Y CelikA Godfrey

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