Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy

Epilepsia
Katherine D HollandPaul S Horn

Abstract

Variants in neuronal voltage-gated sodium channel α-subunits genes SCN1A, SCN2A, and SCN8A are common in early onset epileptic encephalopathies and other autosomal dominant childhood epilepsy syndromes. However, in clinical practice, missense variants are often classified as variants of uncertain significance when missense variants are identified but heritability cannot be determined. Genetic testing reports often include results of computational tests to estimate pathogenicity and the frequency of that variant in population-based databases. The objective of this work was to enhance clinicians' understanding of results by (1) determining how effectively computational algorithms predict epileptogenicity of sodium channel (SCN) missense variants; (2) optimizing their predictive capabilities; and (3) determining if epilepsy-associated SCN variants are present in population-based databases. This will help clinicians better understand the results of indeterminate SCN test results in people with epilepsy. Pathogenic, likely pathogenic, and benign variants in SCNs were identified using databases of sodium channel variants. Benign variants were also identified from population-based databases. Eight algorithms commonly used to predict p...Continue Reading

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Citations

Aug 1, 2019·Thyroid : Official Journal of the American Thyroid Association·Xiao-Ping QiJian-Qiang Zhao
Jul 19, 2018·Journal of the Endocrine Society·Sirawit Ittisoponpisan, Alessia David
Mar 31, 2021·Pediatric Neurology·David M RitterKatherine D Holland

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