Comparison between 100-g glucose tolerance test and two other screening tests for gestational diabetes: combined fasting glucose with risk factors and 50-g glucose tolerance test

São Paulo Medical Journal = Revista Paulista De Medicina
Wilson AyachMarilza Vieira Cunha Rudge

Abstract

Lack of consensus about which screening tests to use for gestational diabetes mellitus (GDM) and difficulties in performing the gold-standard diagnostic test, the 100-g glucose tolerance test (100-g GTT), justify comparison with alternatives. The aim was to compare this with two other screening tests: combined fasting glucose with risk factors (FG + RF) and 50-g GTT. Prospective longitudinal cohort study in the Hospital School of Universidade Federal de Mato Grosso do Sul. The three tests were performed independently on 341 pregnant women. Sensitivity (S), specificity (Sp), positive (PPV) and negative (NPV) predictive values, positive (PLR) and negative (NLR) likelihood ratios, and false-positive (FP) and false-negative (FR) rates obtained with FG + RF and 50-g GTT were compared with values from 100-g GTT. The average one-hour post-intake glucose levels (1hPG) with 50-g and 100-g were compared. Students t test was used in the statistical analysis. FG + RF led more pregnant women (53.9%) to diagnostic confirmation than did 50-g GTT (14.4%). The tests were equivalent for S (86.4 and 76.9%), PPV (98.7 and 98.9%), NLR (0.3 and 0.27) and FR (15.4 and 23.1%). Average 1hPG values were similar: 50-g GTT = 106.8 mg/dl and 100-g GTT = 10...Continue Reading

References

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Citations

Mar 11, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S SalihM Gillmer
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Norman WaughPamela Royle
Jan 21, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·M van LeeuwenB W J Mol
Sep 17, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Louise K K WeileNicolai Lohse
Feb 9, 2012·Revista de saúde pública·Ana Claudia Molina CavassiniMarilza Vieira Cunha Rudge
May 26, 2020·Journal of Epidemiology·Xiuting MoRintaro Mori
Aug 11, 2021·JAMA : the Journal of the American Medical Association·Jennifer PillayLisa Hartling

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