PMID: 15253102Jul 16, 2004Paper

Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Shunichi KojimaHiroyuki Yokoyama

Abstract

Unlike other dihydropyridine calcium channel blockers (CCBs), cilnidipine has been reported to exert an N-type calcium-channel-blocking activity and to reduce sympathetic hyperactivity. This study compared cilnidipine and amlodipine with respect to their effects on renal function and proteinuria. Twenty-eight proteinuric hypertensive outpatients (13 men and 15 women, aged 62+/-2 years) who had been maintained on CCBs for more than 3 months were randomly assigned to a group receiving amlodipine besilate (14 patients) or a group receiving cilnidipine (14 patients). CCBs were increased in dosage or other drugs were added until blood pressure decreased below 140/90 mmHg, but no inhibitors of the renin-angiotensin (RA) system were added or changed in dosage. Before and at 6 and 12 months after randomization, the concentrations of urine protein, urine albumin, serum and urine creatinine (Cr), and serum beta2-microglobulin were determined. The amlodipine group showed a significant increase in proteinuria, while the increase was suppressed in the cilnidipine group. The rate of increase in proteinuria at 12 months was 87% (95% confidence interval (CI) -10 to 184) of the baseline value with amlodipine and 4% (95% CI -69 to 77) of baselin...Continue Reading

References

Sep 1, 1990·The American Journal of Physiology·M M TrachezG Suarez-Kurtz
Oct 24, 1998·Hypertension Research : Official Journal of the Japanese Society of Hypertension·J MinamiH Matsuoka
Apr 29, 1999·The New England Journal of Medicine·G LigtenbergH A Koomans
Jul 17, 1999·European Journal of Pharmacology·H UneyamaN Akaike
Apr 25, 2000·Neuron·E A ErtelW A Catterall
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G L BakrisJ Sowers
Oct 14, 2000·Annual Review of Cell and Developmental Biology·W A Catterall
Aug 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·G W RoseH Suzuki
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Nov 17, 2001·American Journal of Hypertension·S MorimotoM Nakagawa
Jan 5, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·H TomiyamaN Doba
Nov 21, 2002·JAMA : the Journal of the American Medical Association·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Feb 1, 2003·American Journal of Hypertension·Koichi HayashiTakao Saruta
Aug 20, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hirofumi MakinoJun Wada
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira TakaharaHiroshi Yamamoto

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Citations

Feb 5, 2013·North American Journal of Medical Sciences·Ranjan ShettyK L Bairy
Nov 14, 2007·International Heart Journal·Naoto AshizawaKatsusuke Yano
Nov 24, 2005·Clinical and Experimental Hypertension : CHE·Takuya TsuchihashiKenichi Goto
Jun 9, 2011·Clinical and Experimental Hypertension : CHE·Hiroaki MatsuokaUNKNOWN SAKURA Trial Investigators
Jan 11, 2014·Indian Heart Journal·K Sarat Chandra, G Ramesh
Feb 11, 2015·Pharmacology & Therapeutics·Koichiro Kuwahara, Takeshi Kimura
Oct 19, 2007·Kidney International·T FujitaUNKNOWN Cilnidipine versus Amlodipine Randomised Trial for Evaluation in Renal Desease(CARTER) Study Investigators
Jul 10, 2007·Journal of Diabetes and Its Complications·Tomomi FujisawaToshio Ogihara
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tsukasa NakamuraKoichi Node
May 5, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi HoshideKazuyuki Shimada
Jun 2, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuko OhtaMitsuo Iida
Feb 18, 2012·Diabetes Research and Clinical Practice·Shinya FukumotoUNKNOWN Cilnidipine vs L-type calcium channel blockers Evaluation of Antihypertensive Renoprotective Effects in Diabetic patients (C
Sep 5, 2012·Carbohydrate Polymers·Liandong HuQiaofeng Hu
Sep 12, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kai NagasawaKohzo Nagata
Jul 15, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nicolás R RoblesGuido Grassi
Oct 5, 2016·Expert Opinion on Investigational Drugs·J Tamargo, Luis Miguel Ruilope
Feb 5, 2011·American Journal of Nephrology·Shizuka AritomiKosaku Nitta
Sep 22, 2007·Journal of Hypertension·Satoshi MorimotoToshiji Iwasaka
Jul 6, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takeshi SoekiMasataka Sata
Apr 24, 2020·Clinical and Experimental Pharmacology & Physiology·Nessa NaseratunTetsuo Nakata

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