Comparison between clinical and histopathological scoring in cadaveric kidney transplantation and its correlation with posttransplant evolution

Transplantation Proceedings
L ReD Casadei

Abstract

There are several scoring systems, both clinical (Deceased Donor Score [DDS]) and histopathological (Remuzzi [REM]), that attempt to determine acceptability criteria for deceased donor kidney transplant. A retrospective study was performed among a group of kidney transplant recipients to evaluate posttransplant evolution with clinical and histopathological scores. Among 107 first deceased donor kidney transplant patients, 95 had undergone a pretransplant biopsy. Donor age was 38.46 +/- 16.9 years; recipient age: 49.2 +/- 16.3 years; DDS was 15.58 +/- 7.29. REM was 2.89 +/- 1.7. Delayed graft function was 64.2%. Induction therapy was administered to 49.5%. Cold ischemia time (CIT) was 1364 +/- 348 minute. Time on dialysis was 2275 +/- 1501 days. Induction therapy, immunosuppressive regimens, CIT, and time on dialysis were not significantly different among the groups. One-year patient and graft survival were 94.5% and 86%, respectively and 2-year values, 92.6% and 81%, respectively. DDS showed a significant correlation with serum creatinine values over 1 and 2 years. REM did not show a significant association with any events. The differences were sustained after adjusting for other variables. Graft survival maintained a strong co...Continue Reading

References

Dec 10, 1999·Journal of the American Society of Nephrology : JASN·G RemuzziB M Brenner
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Scott L NybergMark D Stegall

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Citations

Sep 20, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B MunivenkatappaB Philosophe
Mar 17, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C J WangB L Kasiske
Dec 30, 2014·BMC Nephrology·Carlo GrifasiAndrea Renda
Dec 17, 2014·Transplantation Proceedings·E Tavares da SilvaA Mota
Mar 25, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Beat MoeckliLéo H Bühler
Feb 22, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Bertram L KasiskeFrancis L Delmonico

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