PMID: 9555972Apr 29, 1998Paper

Comparison between continuous brain tissue pO2, pCO2, pH, and temperature and simultaneous cerebrovenous measurement using a multisensor probe in a porcine intracranial pressure model

Journal of Neurotrauma
Matthias MenzelJ Radke

Abstract

Local brain tissue oxygenation (p(ti)O2) and global cerebrovenous hemoglobin saturation (SjO2) are increasingly used to continuously monitor patients after severe head injury (SHI). In patients, simultaneous local and global oxygen measurements of these types have shown different results regarding the comparability of the findings during changes in CPP and ICP. This is in contrast to theoretical expectations. The aim of this study was to compare p(ti)O2 measurement with cerebrovenous oxygen partial pressure measurement (p(cv)O2) in an animal intracranial pressure model. To this end, a multisensor probe was placed in the left frontoparietal white matter to measure p(ti)O2, pCO2 (p(ti)CO2), pH (pH[ti]), and temperature (t[ti]) while simultaneously measuring these same parameters (p(cv)O2, p(cv)CO2 pH(cv), t[cv]) in the sagittal sinus of 9 pigs under general anesthesia. By stepwise inflating a balloon catheter, placed in supracerebellar infratentorial compartment, ICP was increased and CPP was decreased. The baseline levels of p(ti)O2, p(ti)CO2, and pH(ti) in the noninjured brain tissue showed more heterogeneity compared to the findings in cerebrovenous blood. Both, p(ti)O2 and p(cv)O2 were significantly correlated to the induced ...Continue Reading

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Citations

Jan 5, 2008·Journal of Neurosurgery·Guy RosenthalGeoffrey T Manley
Jan 1, 2009·Journal of Experimental Stroke & Translational Medicine·Shimin LiuH Richard Winn
Jul 6, 2004·Clinical Physiology and Functional Imaging·R A van HulstB Lachmann
May 20, 2003·Clinical Physiology and Functional Imaging·Robert A van HulstBurkhard Lachmann
Jul 16, 2003·Acta Neurologica Scandinavica·R A van HulstB Lachmann
Oct 16, 2003·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·S BarkerH Elderfield
Oct 4, 2006·Current Opinion in Anaesthesiology·W E Hoffman
Feb 10, 2004·Intensive Care Medicine·Robert A van HulstBurkhard Lachmann

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