Comparison between dietary monounsaturated and polyunsaturated fatty acids as regards diet-related diseases

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
M Mutanen

Abstract

We have studied the effects of dietary fatty acid (FA) composition on lipids and lipoproteins, platelet function and other hemostatic variables as well as on the endogenous formation of DNA adducts of malonaldehyde (MA) in healthy subjects in controlled dietary experiments. The FAs studied were monounsaturated oleic acid (OA, 18:1 n-9), n-6-polyunsaturated linoleic acid (LA, 18:2 n-6), n-3 polyunsaturated alpha-linolenic acid (ALA, 18:3 n-3), and two long-chain, n-3 polyunsaturated FAs, eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3). The results indicated that a high OA and high LA diet had comparable effects on lipids and lipoproteins when they replaced saturated FAs in a diet. Furthermore, the effect of ALA did not differ from that of LA in this respect. Both diets also similarly increased in vitro platelet aggregation when compared with high saturated FA baseline diet. In another study the effect of LA and ALA on platelet function was studied. In this study ALA decreased in vitro platelet aggregation when compared with LA. When ALA was compared with EPA + DHA it was found that platelet function and some coagulation and fibrinolysis parameters were mainly affected in a similar manner by ALA and...Continue Reading

References

Jan 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·L M ValstaM Mutanen
Mar 13, 1998·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·H BartschI Velic

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Citations

Aug 8, 2015·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Nov 9, 2001·Journal of Dairy Science·G ValcarceJ Florin-Christensen
May 18, 2012·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Aug 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul D N HebertMehrdad Hajibabaei
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Sep 12, 2008·Journal of Agricultural and Food Chemistry·David G Cornwell, Jiyan Ma

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