Comparison between disk diffusion and agar dilution methods to determine in vitro susceptibility of Corynebacterium spp. clinical isolates and update of their susceptibility

Journal of Global Antimicrobial Resistance
Claudia M BarberisCarlos Vay

Abstract

Although Corynebacterium spp. are part of the microbiota of the skin and mucous membranes, human infections caused by Corynebacterium spp. have been reported and the multidrug resistance pattern of the recovered isolates was emphasised. Due to the usefulness of disk diffusion in daily practice, the purpose of this study was to compare disk diffusion with agar dilution to determine disk diffusion breakpoints and to review the antimicrobial susceptibility of the most frequent Corynebacterium spp. isolated in clinical samples. Susceptibility to 20 antimicrobial agents of 143 Corynebacterium spp. isolates recovered from relevant clinical samples was determined. Comparison between the disk diffusion and agar dilution methods for eight antimicrobial agents was performed to establish new breakpoints using simple linear regression analysis. All of the isolates tested were susceptible to vancomycin, minocycline and linezolid. A typical susceptibility profile to β-lactam antibiotics among the different species included was not observed. Almost all isolates showed resistance to macrolides and lincosamides. Using a simple linear regression method, it was possible to establish breakpoints for penicillin, erythromycin, clindamycin, gentamici...Continue Reading

Citations

Oct 19, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Purva MathurAditya Sharma
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fatima Zahra BamouZsolt Szakonyi
Nov 11, 2020·Computer Methods and Programs in Biomedicine·Salvatore RamponeMarina Paolucci
Feb 11, 2021·Equine Veterinary Journal·Cajsa M IsgrenGina L Pinchbeck
Mar 13, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Katherine V TrinhJames E Saunders

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