Comparison between dynamic gadoxetate-enhanced MRI and 99m Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function

European Radiology
Fadi RassamF M Vos

Abstract

To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection. Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using 99mTc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake function was calculated for both modalities: mebrofenin uptake rate (MUR) and Ki respectively. The FRL was delineated with both SPECT-CT and MRI to calculate the functional share. Blood samples were taken to assess biochemical liver parameters. A total of 20 patients were included. The HBS-derived MUR and the DHCE-MRI-derived mean Ki correlated strongly for both total and FRL function (Pearson r = 0.70, p = 0.001 and r = 0.89, p < 0.001 respectively). There was a strong agreement between the functional share determined with both modalities (ICC = 0.944, 95% CI 0.863-0.978, n = 20). There was a significant negative correlation between liver aminotransferases and bilirubin for both MUR and Ki. Assessment of liver function with DHCE-MRI is comparable with that of 99mTc-mebrofenin HBS and has the pote...Continue Reading

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Citations

Jan 24, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Danielle KaraRobert Brown
Jun 2, 2020·Journal of Hepato-biliary-pancreatic Sciences·Tatsuya OrimoAkinobu Taketomi
Sep 5, 2020·Expert Review of Gastroenterology & Hepatology·Carolina De La Pinta Alonso
Sep 19, 2019·Pharmaceuticals·Julia GreiserMartin Freesmeyer
Jun 19, 2021·Cardiovascular and Interventional Radiology·E A SoykanE G Klompenhouwer

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