Comparison between Lamina Cribrosa Depth and Curvature as a Predictor of Progressive Retinal Nerve Fiber Layer Thinning in Primary Open-Angle Glaucoma.

Ophthalmology. Glaucoma
Eun Ji LeeJean Martial Mari

Abstract

To compare the ability of lamina cribrosa (LC) depth (LCD) and LC curvature to predict the rate of progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG). Observational case series. A total of 114 eyes of 114 patients diagnosed with POAG, in which RNFL thickness had been measured by serial spectral-domain (SD) OCT for at least 2.5 years. The optic nerves of all participants underwent enhanced depth imaging volume scanning, and their circumpapillary RNFL thickness was measured using SD OCT, followed by regular serial measurements of RNFL thickness at intervals of ≥6 months. The LCD from the levels of Bruch's membrane (BM, LCD-BM) and the anterior sclera (AS, LCD-AS), and LC curvature index (LCCI) were measured by SD OCT at 3 locations: superior midperipheral, midhorizontal, and inferior midperipheral. The rate of RNFL thinning over time was determined by linear regression of serial OCT measurements of RNFL thickness. Factors associated with the rate of OCT RNFL thinning. Univariate analysis showed that larger LCD-BM (P = 0.001), LCD-AS (P < 0.001), and LCCI (P < 0.001) were all significantly associated with a faster rate of global RNFL thinning. The LCCI showed a stronger correl...Continue Reading

Citations

May 18, 2019·The British Journal of Ophthalmology·Ji-Ah KimJean Martial Mari
May 22, 2020·The British Journal of Ophthalmology·Tin A TunMichael J A Girard
Apr 10, 2020·Investigative Ophthalmology & Visual Science·Ji-Ah KimJean Martial Mari
Jun 4, 2019·Investigative Ophthalmology & Visual Science·Jeong-Ah KimJean Martial Mari
Aug 2, 2019·Investigative Ophthalmology & Visual Science·Eun Ji LeeHyunjoong Kim
Sep 25, 2020·American Journal of Ophthalmology·Hun Jae WonMin Kyung Song
Jun 11, 2021·Translational Vision Science & Technology·Ou TanDavid Huang
Jun 23, 2021·American Journal of Ophthalmology·Satish K PandaMichaël J A Girard

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