Abstract
Metoprolol is a widely used anti-ischemic drug with a relatively short half-life. To improve patient' compliance and to provide 24-hour coverage, its once daily ORally OSmotic (OROS) formulation was developed. In this multicenter double-blind study, the anti-ischemic effects of metoprolol OROS given once daily at doses of 190 and 285 mg were compared to the regular metoprolol formulation of 100 mg 2 or 3 times daily. Sixty-five patients with stable coronary artery disease, positive exercise tests, and ischemic episodes during daily activity as recorded by ambulatory electrocardiographic monitoring (AEM) were included. In the OROS group, 23 patients completed all 3 treatment periods. In these patients, the number of myocardial ischemic episodes decreased from 239 on placebo to 128 during the 190 mg/day dose (p < 0.0001) and to 86 during the 285 mg/day treatment period (p < 0.0001). In the metoprolol group, there were 204 episodes at baseline and 142 and 140 during the 100 mg 2 or 3 times daily treatment periods (p < 0.0001 for both). During exercise testing, time to 1-mm ST depression increased significantly in the OROS group from 6.3 minutes at baseline to 7.1 and 9.6 minutes during 190- and 285-mg treatment periods. In the met...Continue Reading
References
Mar 6, 1992·The American Journal of Cardiology·M JuneauD Waters
Jul 1, 1991·Circulation·P ThérouxE Dempsey
Mar 15, 1991·The American Journal of Cardiology·D TzivoniA Caspi
Apr 1, 1991·The American Journal of Cardiology·J A HillC J Pepine
May 1, 1991·The American Journal of Cardiology·D ArdissinoI Wahlqvist
Dec 1, 1990·Circulation·P H StoneK Raby
Oct 1, 1990·Journal of the American College of Cardiology·W W KleinJ Dusleag
Sep 15, 1990·The American Journal of Cardiology·D HausmannP R Lichtlen
Mar 1, 1989·Circulation·S N WillichP H Stone
Jan 1, 1989·International Journal of Cardiology·P K RønnevikL Woie
Nov 15, 1988·The American Journal of Cardiology·J R Morse
Mar 1, 1988·The American Journal of Cardiology·G OlssonS Zetterquist
Apr 1, 1988·Circulation·W FrishmanJ Strom
Sep 1, 1987·The American Journal of Cardiology·G A ImperiC J Pepine
Aug 15, 1986·The American Journal of Cardiology·D TzivoniS Stern
Feb 1, 1987·Circulation·M B RoccoA P Selwyn
May 1, 1974·British Heart Journal·S Stern, D Tzivoni
Jun 1, 1995·Journal of the American College of Cardiology·D ArdissinoI Wahlqvist
Jan 1, 1995·Journal of the American College of Cardiology·T von Arnim
Mar 1, 1995·Journal of the American College of Cardiology·R F DaviesK Foris
Dec 1, 1994·The American Journal of Cardiology·M C PortegiesK I Lie
Mar 1, 1993·Circulation·J BenhorinD Tzivoni
Apr 15, 1993·The American Journal of Cardiology·S C SiuR W Nesto
Jun 1, 1993·Journal of the American College of Cardiology·S BorzakP H Stone