Comparison between non-septic and septic cases in stone-related obstructive acute pyelonephritis and risk factors for septic shock: A multi-center retrospective study

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Fukashi YamamichiMasato Fujisawa

Abstract

This study assessed risk factors for septic shock in patients with obstructive acute pyelonephritis (APN) associated with upper urinary tract calculi in a multi-center retrospective study. We studied 143 patients admitted to 4 hospitals in Japan with obstructive APN associated with upper urinary tract calculi. Data on gender, age, hypertension, diabetes, neurological disease or malignant disease, laboratory data (white blood cell (WBC) and C-reactive protein (CRP)), drainage, and bacterial strains including Escherichia coli in the non-septic and septic groups were collected. Risk factors for septic shock were analyzed by univariate and multivariate statistical analyses. There were a total of 107 non-septic cases (74.8%) and 36 septic cases (25.2%). The commonest strains of urinary tract infection-causative bacteria were E. coli in the non-septic group (23 cases, 21.5%) and septic group (13 cases, 36.1%) (p > 0.05). Emergency drainage was administered in 74.8% of the non-septic group and 97.2% of the septic group (p > 0.05). Meropenem was most often used as the initial treatment in the non-septic group (20 cases, 18.7%) and septic group (22 cases, 61.1%) (p < 0.0001). Risk factors for septic shock in multivariate analyses were d...Continue Reading

Citations

Jan 29, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·HyeJin ShiKyong Ran Peck
Dec 5, 2019·Journal of X-ray Science and Technology·Zejian ZhangYuanyuan Zhang
Dec 15, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Zi-Hao XuJian-Lin Lv
May 14, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Natasha SebastianHaim Arie Abenhaim
Jun 1, 2021·ACS Omega·Buddhika GayaniManjula Manoji Weerasekera
May 21, 2021·Urology·George E Koch, Niels V Johnsen
Aug 3, 2021·Urologia·Georges Abi TayehElie El Helou

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