Comparison between number of basophils, blood histamine, and histamine release in cancer and noncancer patients.

The Journal of Allergy and Clinical Immunology
L GaloppinC Burtin

Abstract

In cancer patients with primary tumor with or without metastasis or metastasis alone, by comparison with healthy subjects and noncancer patients, the decrease in blood histamine levels is due to a decrease in total basophil number. These basophils have a normal content of histamine (1 to 2 pg per basophil) and are able to release histamine. The percentage of anti IgE-induced histamine release is not significantly different than in noncancer patients. The scarcity of basophils in cancer patients is not due to a leukopenia. Blood histamine levels and total basophil number are normal in patients after successful excision of their primary tumor without metastasis.

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Citations

Sep 1, 1996·Journal of Clinical Epidemiology·T ShirakawaK Morimoto
Mar 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M den OudenJ W van Wersch
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May 1, 2021·International Journal of Molecular Sciences·Izabela SiemińskaJarek Baran

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Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.