Comparison between Optical COherence tomography guidance and Angiography guidance in percutaneous coronary intervention (COCOA): Study protocol for a randomized controlled trial

Journal of cardiology
Takashi KuboTakashi Akasaka

Abstract

Optical coherence tomography (OCT) is increasingly used as an adjunct to coronary angiography for guiding percutaneous coronary intervention (PCI). The current consensus on PCI is that the large final stent area offers the best chance of a good late clinical outcome. Since OCT provides more accurate information about the coronary artery and implanted stents, OCT-guided stent implantation is expected to achieve greater stent expansion than angiography guidance alone. Therefore, we designed the COCOA (Comparison between Optical COherence tomography guidance and Angiography guidance in percutaneous coronary intervention) study to evaluate whether OCT-guided stent implantation would result in a minimum stent area greater than that achieved with angiography guidance alone. The COCOA study is a large-scale, multicenter, single country (Japan), prospective randomized controlled, open-label, parallel group, superiority study comparing OCT-guided PCI with angiography-guided PCI. The eligible patients (n=550) are randomly allocated in a 1:1 ratio to receive either OCT-guided PCI or angiography-guided PCI. PCI is performed using the everolimus-eluting stent in accordance with certain criteria of OCT or angiography for optimal stent implan...Continue Reading

Associated Clinical Trials

References

May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
May 10, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Sep 10, 2013·JACC. Cardiovascular Imaging·Takashi KuboShaosong Zhang
Mar 24, 2015·JACC. Cardiovascular Imaging·Takashi KuboTakashi Akasaka
Oct 1, 2016·Circulation. Cardiovascular Interventions·Yasushi InoTakashi Akasaka

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Citations

Oct 30, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroki EmoriTakashi Akasaka
Jan 22, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Amir Kh M KhalifaTakashi Akasaka

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