Comparison between procalcitonin and C-reactive protein for early diagnosis of children with sepsis or septic shock.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
José R FiorettoSandra M Q Ricchetti

Abstract

The objective of the paper is to examine the behavior of C-reactive protein (CRP) and procalcitonin (PCT) in the first 12 h of admission and verify which performs better to differentiate children with septic conditions. Septic children aged between 28 days and 14 years were divided into sepsis (SG; n = 46) and septic shock (SSG; n = 41) groups. CRP and PCT were measured at admission (T0) and 12 h later (T12 h). PCT results were classed as: 0.5 ng/ml = sepsis unlikely; >or=0.5 to <2 = sepsis possible; >or=2 to <10 = systemic inflammation; >or=10 = septic shock. At T0, there was a higher frequency of SSG with PCT >10 compared to SG [SSG: 30 (73.1%) > SG: 14 (30.4%); P < 0.05]. Similar results were observed at T12 h. Pediatric Risk of Mortality I score was significantly higher for SSG patients with higher PCT than SG patients. CRP levels were not statistically different for groups and time points. PCT was better than CRP for diagnosing sepsis and septic shock, mainly at admission, and is related to disease severity.

References

Nov 1, 1988·Critical Care Medicine·M M PollackP R Getson
Sep 1, 1987·The Journal of Pediatrics·J D WilkinsonC M Steinhart
Apr 13, 1999·Critical Care Medicine·H UgarteJ L Vincent
Nov 23, 2000·Intensive Care Medicine·E SuprinR Thomas
Apr 16, 2002·Acta Anaesthesiologica Scandinavica·E RuokonenJ Takala
May 7, 2002·The American Journal of Emergency Medicine·Hakan GuvenYuksel Bek
Jun 20, 2002·Critical Care Medicine·Joseph A CarcilloUNKNOWN American College of Critical Care Medicine Task Force Committee Members
Jul 20, 2002·International Journal of Antimicrobial Agents·E D CarrolC A Hart
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
May 17, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Juan Casado-FloresMonserrat Nieto
Jun 10, 2003·Critical Care Medicine·Aldo LuzzaniAlberto Merlini
Jan 15, 2004·Anaesthesia and Intensive Care·K BellE M Benson
Apr 20, 2004·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Management Guidelines Committee
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Nov 27, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chieko Mitaka
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Sep 22, 2005·Current Opinion in Critical Care·Michael Meisner
Mar 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Shahin GaïniSvend Stenvang Pedersen
Feb 24, 2007·The Lancet Infectious Diseases·Benjamin M P TangAnthony S McLean
Oct 12, 2007·Journal of Paediatrics and Child Health·Wojciech M Fendler, Andrzej J Piotrowski
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerUNKNOWN World Federation of Societies of Intensive and Critical Care Medicine
May 23, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Liliana SimonFrance Gauvin
Jun 21, 2008·Cytokine·José R FiorettoCarlos R Padovani

❮ Previous
Next ❯

Citations

Feb 23, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G N MatwiyoffM Daheshia
Mar 30, 2012·International Journal of Legal Medicine·Bettina SchragCristian Palmiere
May 4, 2013·Pediatric Clinics of North America·Haifa MtawehRajesh K Aneja
Jun 19, 2012·Diagnostic Microbiology and Infectious Disease·Stefan Riedel
Nov 8, 2011·The Journal of Emergency Medicine·Ephraim L TsalikChristopher W Woods
Oct 19, 2011·Acta Paediatrica·Sofia Ygberg, Anna Nilsson
Aug 13, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Suwen QiHuisheng Zhang
May 20, 2015·Biomarkers in Medicine·Natalia KiszewskaElżbieta Adamkiewicz-Drożyńska
Dec 16, 2016·PLoS Pathogens·Jeroen SlaatsMihai G Netea
Jun 29, 2011·Expert Review of Molecular Diagnostics·Terence Chan, Frank Gu
Jan 19, 2018·Biomarker Insights·Sara BobilloIolanda Jordan
Dec 22, 2010·Expert Review of Anti-infective Therapy·Stephen W Standage, Hector R Wong
Jan 31, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·John J KotulaJeffrey J Cies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.