Comparison Between Prognostic Classifications in De Novo Metastatic Hormone Sensitive Prostate Cancer

Targeted Oncology
Roberto IacovelliGiampaolo Tortora

Abstract

The CHAARTED and LATITUDE trials demonstrated improved outcomes with docetaxel or abiraterone plus androgen deprivation therapy in metastatic hormone sensitive prostate cancer (mHSPC) using two different prognostic scores. The aim of our study was to assess the concordance between the two scores and if these retained their prognostic value exclusively in de novo mHSPC. De novo mHSPC patients referring to our institution were retrospectively stratified according to the CHAARTED and LATITUDE classifications: high volume/high risk (HV/HR), low-volume/low-risk (LV/LR), and HVorHR (HV/LR and LV/HR). The Kaplan-Meier method and Cox proportional-hazard models were used to estimate hazard ratios for overall survival. The study population included 106 patients. Concordance between the CHAARTED and LATITUDE classifications was observed in 86.8% of cases (65.1% HV/HR, 21.7% LV/LR), while 13.2% of patients fulfill the criteria of only one of the two classifications (HVorHR). When analyzed independently, the CHAARTED and LATITUDE classifications maintained their prognostic value (mOS 28.2 months in HV versus 60.9 months in LV, p = 0.006; 28.2 months in HR versus 40.6 months in LR, p = 0.017). The LR/LV population showed significantly longer...Continue Reading

References

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Jun 6, 2017·The New England Journal of Medicine·Karim FizaziUNKNOWN LATITUDE Investigators
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Aug 20, 2018·Cancer Treatment Reviews·Claudia MosilloGiampaolo Tortora
Aug 25, 2018·Clinical Genitourinary Cancer·Roberto IacovelliGiampaolo Tortora

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Citations

Nov 27, 2019·Cancer·Brandon BernardSrikala S Sridhar
Jun 24, 2020·Cancers·Savvas StokidisConstantin N Baxevanis
Jul 12, 2020·Prostate Cancer and Prostatic Diseases·Roberto IacovelliGiampaolo Tortora
Jul 16, 2020·Clinical Genitourinary Cancer·Giandomenico RovielloAlberto D'Angelo
May 6, 2021·Journal of Cancer Research and Clinical Oncology·Bumjin LimChoung-Soo Kim

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