Comparison between terminal slope rate constant and "slope/intercept" as measures of glomerular filtration rate using the single-compartment simplification

European Journal of Nuclear Medicine
A M PetersD Lui

Abstract

Several whole-body variables are available for indexing glomerular filtration rate (GFR), including extracellular fluid volume (ECF volume, ECV), which has the advantage that GFR based only on the terminal exponential, alpha 2, of the chromium-51 ethylene diamine tetraacetic acid (51Cr-EDTA) plasma clearance curve is a measure already indexed for ECV. This slope-only method, however, is open to the theoretical criticism of a lack of robustness not present in the more conventional slope/intercept method, which generates GFR in absolute units before indexation to body surface area (BSA). To further evaluate the slope-only method, a large database of routine three-sample GFR measurements, based on 51Cr-EDTA, was analysed with the aim of comparing GFR/BSA with GFR/ECV, identifying the main sources of error in their respective measurements and explaining why they might be discrepant. The database was subdivided into 304 patients (group A) in whom the correlation coefficient of the fit to the three data points was greater than 0.99 and 31 patients in whom it was less than 0.99 (noisy data; group B). There was modest agreement between GFR/BSA and GFR/ECV in group A (r = 0.77; mean ratio 1.01 +/- 0.21). The difference between them corr...Continue Reading

Citations

Nov 1, 2012·Nuclear Medicine Communications·Lars Jødal, Jens Brøchner-Mortensen
Oct 7, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ralph A MagnottiPeter M Marietta
Jul 22, 2004·Nuclear Medicine Communications·John S FlemingUNKNOWN British Nuclear Medicine Society
Oct 27, 2004·Journal of Magnetic Resonance Imaging : JMRI·Laurence AnnetBernard E Van Beers

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