Comparison between the Beta-2 Microglobulin-Based Equation and the CKD-EPI Equation for Estimating GFR in CKD Patients in China: ES-CKD Study.

Kidney Diseases
Lili YueXin Du

Abstract

Beta-2 microglobulin (B2M) and cystatin C are novel glomerular filtration markers that have a stronger association with adverse outcomes than creatinine. The B2M-based glomerular filtration rate (GFR) estimating equation was built in 2016. Several new creatinine and cystatin C equations were developed in 2019 in China. However, external validation of these new equations remains to be seen. This is a prospective cohort study. The equations were validated in a population totaling 830 participants (median age 62 years). These equations include the B2M-based equation (built in 2016), three CKD-EPI equations (built in 2009 and 2012), three Yang-Du equations (C-CKD-EPIscr, C-CKD-EPIcys, and C-CKD-EPIscr-cys equations, all of which were Chinese-modified CKD-EPI equations developed by Yang et al. in 2019), and a Xiangya equation (a creatinine-based equation built in the Third Xiangya Hospital in 2019). The estimated GFR (eGFR) calculated separately by 8 equations (B2M GFR, CKD-EPIscr, CKD-EPIcys, CKD-EPIscr-cys, C-CKD-EPIscr, C-CKD-EPIcys, C-CKD-EPIscr-cys, and Xiangya equations) was compared with the reference GFR (rGFR) measured by the <sup>99m</sup>Tc-DTPA renal dynamic imaging method. Participants were divided into CKD stage 1-5 sp...Continue Reading

References

May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 7, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brad C AstorJosef Coresh
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Apr 10, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Morgan E GramsJosef Coresh
Jul 26, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph A Vassalotti, Beth Piraino
Sep 10, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xun LiuTan-qi Lou
Mar 1, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fang WangUNKNOWN China National Survey of CKD Working Group
Sep 13, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerAndrew S Levey
Apr 23, 2016·The Lancet Global Health·Melody Sherwood, Peter A McCullough
Aug 1, 2016·Seminars in Nephrology·Priya Vart, Morgan E Grams
Sep 25, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xun LiuUNKNOWN CRIC (Chronic Renal Insufficiency Cohort) Study Investigators
Apr 4, 2017·Korean journal of anesthesiology·Sang Gyu Kwak, Jong Hae Kim

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