Comparison between the Prebolus T1 Measurement and the Fixed T1 Value in Dynamic Contrast-Enhanced MR Imaging for the Differentiation of True Progression from Pseudoprogression in Glioblastoma Treated with Concurrent Radiation Therapy and Temozolomide Chemotherapy.

AJNR. American Journal of Neuroradiology
J G NamC-H Sohn

Abstract

Glioblastoma is the most common primary brain malignancy and differentiation of true progression from pseudoprogression is clinically important. Our purpose was to compare the diagnostic performance of dynamic contrast-enhanced pharmacokinetic parameters using the fixed T1 and measured T1 on differentiating true from pseudoprogression of glioblastoma after chemoradiation with temozolomide. This retrospective study included 37 patients with histopathologically confirmed glioblastoma with new enhancing lesions after temozolomide chemoradiation defined as true progression (n = 15) or pseudoprogression (n = 22). Dynamic contrast-enhanced pharmacokinetic parameters, including the volume transfer constant, the rate transfer constant, the blood plasma volume per unit volume, and the extravascular extracellular space per unit volume, were calculated by using both the fixed T1 of 1000 ms and measured T1 by using the multiple flip-angle method. Intra- and interobserver reproducibility was assessed by using the intraclass correlation coefficient. Dynamic contrast-enhanced pharmacokinetic parameters were compared between the 2 groups by using univariate and multivariate analysis. The diagnostic performance was evaluated by receiver operati...Continue Reading

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S BlümlW J Lorenz
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean C L DeoniTerry M Peters
Oct 28, 2003·Journal of Magnetic Resonance Imaging : JMRI·Brian M DaleJeffrey L Duerk
Jan 1, 1950·Cancer·W J YOUDEN
Oct 9, 2004·Molecular Interventions·C Shun Wong, Albert J Van der Kogel
Jun 23, 2005·Journal of Magnetic Resonance Imaging : JMRI·Sílvia Nosàs-GarciaStefan Delorme
Feb 3, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kim MouridsenLeif Ostergaard
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Mark HaackeJaladhar Neelavalli
May 3, 2008·The Lancet Oncology·Dieta BrandsmaMartin J van den Bent
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Aug 13, 2015·Journal of Magnetic Resonance Imaging : JMRI·Zhiming LiXiaoming Yang
Aug 16, 2015·Journal of Neuro-oncology·Alissa A ThomasRobert J Young

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Citations

May 15, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Dong Jae ShinEun Jung Lee
Aug 21, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ashley M StokesC Chad Quarles

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